肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2011年
10期
649-652
,共4页
氟脱氧葡萄糖F18%正电子发射断层显像术%计算机断层摄影术%氩氦刀%肺肿瘤
氟脫氧葡萄糖F18%正電子髮射斷層顯像術%計算機斷層攝影術%氬氦刀%肺腫瘤
불탈양포도당F18%정전자발사단층현상술%계산궤단층섭영술%아양도%폐종류
Fluorodeoxyglucose F18%Positron-emission tomography%Tomography,computed%Ar-He cryoablation%Lung neoplasms
目的 观察肺癌经氩氦刀治疗后18-脱氧葡萄糖-正电子发射型计算机断层显像与CT同机融合图像( 18F-FDG PET-CT)显像的变化,寻找氩氦刀治疗后近期疗效评价的方法.方法 对15例肺癌患者19个病灶进行氩氦刀治疗,在治疗后1～6个月内完成18F-FDG PET-CT检查.其中7例患者治疗前后进行了18F-FDG PET-CT检查,8例仅治疗后进行了18F-FDG PET-CT检查,但可自身比较.冷冻治疗组织和对照组织最大标准化摄取值( SUVmax)的比较采用配对资料的t检验,冷冻治疗后PET-CT时间间隔与SUVmax检测采用重复测量方差分析.结果 术后18F-FDGPET-CT检查显示19个氩氦刀冷冻病灶,13个未见放射性核素的浓聚,在随访过程中未见肿瘤生长.2例纵隔型肺癌周边残留,表现为边界清楚的“梨形”放射性缺损,随访4个月左右发现肿瘤开始向周围扩展；4例冷冻的肿瘤组织内表现为放射性核素浓聚,均在半年内复发.肺内单发肿瘤氩氦刀治疗前后SUVmax定性和定量检测结果显示,差异有统计学意义(t=3.784,P＜ 0.05)；但是对于冷冻治疗与PET-CT检查间隔时间对SUVmax变化的影响差异无统计学意义( F=0.106,P＞ 0.05).结论 18F-FDG PET-CT图像真实地反映了氩氦刀冷冻治疗的范围及效果,是氩氦刀冷冻治疗后近期效果评价较理想的方法.
目的 觀察肺癌經氬氦刀治療後18-脫氧葡萄糖-正電子髮射型計算機斷層顯像與CT同機融閤圖像( 18F-FDG PET-CT)顯像的變化,尋找氬氦刀治療後近期療效評價的方法.方法 對15例肺癌患者19箇病竈進行氬氦刀治療,在治療後1～6箇月內完成18F-FDG PET-CT檢查.其中7例患者治療前後進行瞭18F-FDG PET-CT檢查,8例僅治療後進行瞭18F-FDG PET-CT檢查,但可自身比較.冷凍治療組織和對照組織最大標準化攝取值( SUVmax)的比較採用配對資料的t檢驗,冷凍治療後PET-CT時間間隔與SUVmax檢測採用重複測量方差分析.結果 術後18F-FDGPET-CT檢查顯示19箇氬氦刀冷凍病竈,13箇未見放射性覈素的濃聚,在隨訪過程中未見腫瘤生長.2例縱隔型肺癌週邊殘留,錶現為邊界清楚的“梨形”放射性缺損,隨訪4箇月左右髮現腫瘤開始嚮週圍擴展；4例冷凍的腫瘤組織內錶現為放射性覈素濃聚,均在半年內複髮.肺內單髮腫瘤氬氦刀治療前後SUVmax定性和定量檢測結果顯示,差異有統計學意義(t=3.784,P＜ 0.05)；但是對于冷凍治療與PET-CT檢查間隔時間對SUVmax變化的影響差異無統計學意義( F=0.106,P＞ 0.05).結論 18F-FDG PET-CT圖像真實地反映瞭氬氦刀冷凍治療的範圍及效果,是氬氦刀冷凍治療後近期效果評價較理想的方法.
목적 관찰폐암경아양도치료후18-탈양포도당-정전자발사형계산궤단층현상여CT동궤융합도상( 18F-FDG PET-CT)현상적변화,심조아양도치료후근기료효평개적방법.방법 대15례폐암환자19개병조진행아양도치료,재치료후1～6개월내완성18F-FDG PET-CT검사.기중7례환자치료전후진행료18F-FDG PET-CT검사,8례부치료후진행료18F-FDG PET-CT검사,단가자신비교.냉동치료조직화대조조직최대표준화섭취치( SUVmax)적비교채용배대자료적t검험,냉동치료후PET-CT시간간격여SUVmax검측채용중복측량방차분석.결과 술후18F-FDGPET-CT검사현시19개아양도냉동병조,13개미견방사성핵소적농취,재수방과정중미견종류생장.2례종격형폐암주변잔류,표현위변계청초적“리형”방사성결손,수방4개월좌우발현종류개시향주위확전；4례냉동적종류조직내표현위방사성핵소농취,균재반년내복발.폐내단발종류아양도치료전후SUVmax정성화정량검측결과현시,차이유통계학의의(t=3.784,P＜ 0.05)；단시대우냉동치료여PET-CT검사간격시간대SUVmax변화적영향차이무통계학의의( F=0.106,P＞ 0.05).결론 18F-FDG PET-CT도상진실지반영료아양도냉동치료적범위급효과,시아양도냉동치료후근기효과평개교이상적방법.
Objective To observe the change of 18F-Fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET-CT) imaging on lung tumors after treatment of Argon-Helium (Ar-He) cryoablation,and to search the measure for evaluating the short-term curative effect after treatment of Ar-He cryoablation.Methods 19 focuses of 15 patients had completed the treatment of Ar-He cryoablation.All of patients imaged with 18F-FDG PET-CT in six months after Ar-He cryoablation.7 patients of all imaged with 18F-FDG PET-CT pre- and after Ar-He cryoablation.The others only imaged with 18F-FDG PET-CT after cryoablation,but these focuses could compare with tissues near the focus or other tumors in themselves.Results 18F-FDG PET-CT imaging found that there was no accumulation of radionuclide in 13 of 19 focuses after cryoablation and there was no new tumor in follow-up.Two target region of cryoablation,which grew up in mediastinum,were found radiation defect with distinct boundary and expanding outward during 4 months.The other 4 focuses recurred during 6 months in which there was accumulation of radionuclide after cryoablation.There was significant change about SUVmax of focuses after cryoablation by qualitative and quantitative analysis (t =3.784,P ＜0.05).But the changes of SUVmax had no significant difference in different time,between cryoablation and PET-CT imaging (F =0.106,P ＞0.05).Conclusion 18F-FDG PET-CT imaging really reveals the range and effect of Ar-He cryoablation.It is an optimal measure for evaluating the short term curative effect after Ar-He cryoablation.
