CAJ | 학술논문

目的对比研究一氧化碳中毒后迟发性脑病(DEACMP)患者在高压氧(HBO)联合药物治疗前、后单光子发射计算机断层成像(SPECT)脑血流灌注显像结果,并对其优越性及临床意义进行评价.方法 34例DEACMP患者接受20～40次HBO联合药物治疗,并在治疗前、后用双半胱乙酯(~(99m)Tc-ECD)脑SPECT血流灌注扫描半定量法进行疗效监测和对比分析.结果 HBO治疗后,DEACMP患者脑血流灌注减低区有明显改善,脑SPECT血流灌注半定量值与治疗前比较,差异有统计学意义(P<0.05),而治疗前、后脑磁共振显像无明显差异.结论脑SPECT血流灌注半定量法显像在DEACMP的诊断和HBO治疗的疗效监测中可起重要作用.
목적 대비연구일양화탄중독후지발성뇌병(DEACMP)환자재고압양(HBO)연합약물치료전、후단광자발사계산궤단층성상(SPECT)뇌혈류관주현상결과,병대기우월성급림상의의진행평개.방법 34례DEACMP환자접수20～40차HBO연합약물치료,병재치료전、후용쌍반광을지(~(99m)Tc-ECD)뇌SPECT혈류관주소묘반정량법진행료효감측화대비분석.결과 HBO치료후,DEACMP환자뇌혈류관주감저구유명현개선,뇌SPECT혈류관주반정량치여치료전비교,차이유통계학의의(P<0.05),이치료전、후뇌자공진현상무명현차이.결론 뇌SPECT혈류관주반정량법현상재DEACMP적진단화HBO치료적료효감측중가기중요작용.
Objective To evaluate the effects of hyperbaric oxygen (HBO) combined with drug therapy on patients with delayed encephalopathy caused by carbon monoxide poisoning ( COP). Methods Twenty to forty sessions of HBO therapy were used to treat 34 COP patients. Assessment relied on 99mTc-ethyl cysteinate dimer (~(99m)Tc-ECD) single photon emission computed tomography (SPECT) imaging of cerebral perfusion before and after treatment. Results After HBO therapy, cerebral perfusion in the COP patients improved significantly. There was a significant difference of the SPECT images before and after treatment. Conclusions SPECT imaging of cerebral perfusion can play an important role in the diagnosis of delayed encephalopathy caused by carbon monoxide poisoning, and it can be used for the therapeutic surveillance of HBO treatment.