CAJ | 학술논문

瘦素可通过多种信号转导通路促进胃癌细胞增殖,并对胃癌新生血管的形成发挥重要作用.瘦素在胃癌组织中的表达水平显著高于正常胃黏膜,且与胃癌的分化、肿瘤大小、远处转移等因素相关.瘦素是胃癌患者的一项预后因素,同时也可能成为胃癌治疗的新靶点.
수소가통과다충신호전도통로촉진위암세포증식,병대위암신생혈관적형성발휘중요작용.수소재위암조직중적표체수평현저고우정상위점막,차여위암적분화、종류대소、원처전이등인소상관.수소시위암환자적일항예후인소,동시야가능성위위암치료적신파점.
Leptin promotes proliferation of cancer cells via various signal transduction pathways and contributes to angiogenesis in gastric cancer. Leptin expression level is significantly higher in gastric cancer than in normal gastric mucous tissues, and correlates with clinicopathological features such as differentiation,tumor size and distant metastasis. Leptin has become a prognostic factor and a new therapy target of gastric cancer.