中华肝胆外科杂志
中華肝膽外科雜誌
중화간담외과잡지
CHINESE JOURNAL OF HEPATOBILIARY SURGERY
2011年
6期
479-483
,共5页
王伟艺%唐文皓%袁祖荣%唐健雄%王巍%涂彦渊%丁皓
王偉藝%唐文皓%袁祖榮%唐健雄%王巍%塗彥淵%丁皓
왕위예%당문호%원조영%당건웅%왕외%도언연%정호
胰腺肿瘤%胰腺切除术%复发%血管内皮生长因子C%多因素分析
胰腺腫瘤%胰腺切除術%複髮%血管內皮生長因子C%多因素分析
이선종류%이선절제술%복발%혈관내피생장인자C%다인소분석
Pancreatic neoplasm%Curative resection%Recurrence%Vascular endothelial growth factor-C%Multivariate analysis
目的 探讨血管内皮生长因子C(VEGF-C)表达及多种临床病理因素在预测胰腺癌根治术后复发的价值.方法 应用Envision免疫组化法测定47例胰腺癌根治性切除标本中胰腺癌组织和自身胰腺正常组织中VEGF-C的表达.通过Kaplan-Meier生存分析和Cox风险比例模型,评估VEGF-C和各临床病理因素对胰腺癌根治术后复发的影响.结果 VEGF-C在胰腺癌组织中的表达比例及其在自身正常胰腺组织中的表达比例分别为29例(61.7%)、7例(14.9%),VEGF-C在胰腺癌组织中的表达比例明显高于其在自身正常胰腺组织中的表达(P=0.018).胰腺癌根治术后患者无病中位生存期为11.9个月,平均为(18.4±2.4)个月.1年、2年、3年累计无病生存率分别为46.8%、23.4%和14.4%.VEGF-C的表达与淋巴结转移有显著的相关性(P=0.036).单因素生存分析显示VEGF-C(P=0.020)、肿瘤直径(P=0.013)、年龄(P=0.057)、术后辅助化疗(P=0.017)与无病生存期明显相关.Cox回归多因素分析显示,VEGF-C(P=0.009),肿瘤直径(P=0.010)、术后辅助化疗(P=0.017)是胰腺癌根治术后患者无病生存期独立的预后因素.结论 VEGF-C在胰腺癌组织中表达明显增高,VEGF-C的表达与淋巴结转移有显著的相关性,VEGF-C可作为判断胰腺癌根治术后患者无病生存期的独立指标.
目的 探討血管內皮生長因子C(VEGF-C)錶達及多種臨床病理因素在預測胰腺癌根治術後複髮的價值.方法 應用Envision免疫組化法測定47例胰腺癌根治性切除標本中胰腺癌組織和自身胰腺正常組織中VEGF-C的錶達.通過Kaplan-Meier生存分析和Cox風險比例模型,評估VEGF-C和各臨床病理因素對胰腺癌根治術後複髮的影響.結果 VEGF-C在胰腺癌組織中的錶達比例及其在自身正常胰腺組織中的錶達比例分彆為29例(61.7%)、7例(14.9%),VEGF-C在胰腺癌組織中的錶達比例明顯高于其在自身正常胰腺組織中的錶達(P=0.018).胰腺癌根治術後患者無病中位生存期為11.9箇月,平均為(18.4±2.4)箇月.1年、2年、3年纍計無病生存率分彆為46.8%、23.4%和14.4%.VEGF-C的錶達與淋巴結轉移有顯著的相關性(P=0.036).單因素生存分析顯示VEGF-C(P=0.020)、腫瘤直徑(P=0.013)、年齡(P=0.057)、術後輔助化療(P=0.017)與無病生存期明顯相關.Cox迴歸多因素分析顯示,VEGF-C(P=0.009),腫瘤直徑(P=0.010)、術後輔助化療(P=0.017)是胰腺癌根治術後患者無病生存期獨立的預後因素.結論 VEGF-C在胰腺癌組織中錶達明顯增高,VEGF-C的錶達與淋巴結轉移有顯著的相關性,VEGF-C可作為判斷胰腺癌根治術後患者無病生存期的獨立指標.
목적 탐토혈관내피생장인자C(VEGF-C)표체급다충림상병리인소재예측이선암근치술후복발적개치.방법 응용Envision면역조화법측정47례이선암근치성절제표본중이선암조직화자신이선정상조직중VEGF-C적표체.통과Kaplan-Meier생존분석화Cox풍험비례모형,평고VEGF-C화각림상병리인소대이선암근치술후복발적영향.결과 VEGF-C재이선암조직중적표체비례급기재자신정상이선조직중적표체비례분별위29례(61.7%)、7례(14.9%),VEGF-C재이선암조직중적표체비례명현고우기재자신정상이선조직중적표체(P=0.018).이선암근치술후환자무병중위생존기위11.9개월,평균위(18.4±2.4)개월.1년、2년、3년루계무병생존솔분별위46.8%、23.4%화14.4%.VEGF-C적표체여림파결전이유현저적상관성(P=0.036).단인소생존분석현시VEGF-C(P=0.020)、종류직경(P=0.013)、년령(P=0.057)、술후보조화료(P=0.017)여무병생존기명현상관.Cox회귀다인소분석현시,VEGF-C(P=0.009),종류직경(P=0.010)、술후보조화료(P=0.017)시이선암근치술후환자무병생존기독립적예후인소.결론 VEGF-C재이선암조직중표체명현증고,VEGF-C적표체여림파결전이유현저적상관성,VEGF-C가작위판단이선암근치술후환자무병생존기적독립지표.
Objective To investigate the prognostic value of vascular endothelial growth factor C (VEGF-C) and clinicopathologic indexes in predicting recurrence following curative resection of pancreatic cancer. Methods The expressions of VEGF-C of 47 patients who underwent curative resection for curative pancreatic cancer resection were detected by Envision immunohistochemical methods. The effects of VEGF-C and clinicopathologic indexes on recurrence were assessed by the Kaplan-Meier and Cox proportional hazards model. Results The positive rates of VEGF-C were 61. 7% in = 29) and 14. 9%(n = 7), respectively, in pancreatic cancer and normal pancreatic tissues. The positive expression of VEGF-C in pancreatic carcinoma was obviously higher than the normal pancreatic tissues (P = 0. 018). The median disease-free survival time was 11. 9 months, the average disease-free survival time was 18. 4 + 2. 4 months, and the cumulative 1-year, 2-year and 3-year actuarial recurrence free survival rates were 46. 8%, 23. 4%, 14. 4%, respectively. There was a significant correlation between the VEGF-C expression and lymph node metastasis in pancreatic cancer (P = 0. 036). On Kaplan-Meier analysis, VEGF-C (P = 0. 020), tumor diameter (P = 0. 013), age (P = 0. 057) and adjuvant chemotherapy (P=0. 017) were associated with disease-free survival time. Multivariate analysis showed VEGF-C (P = 0. 009), tumor diameter (P = 0. 010) and adjuvant chemotherapy (P = 0. 017)were independent prognostic factors of disease-free survival after surgery for pancreatic cancer.Conclusion The expression of VEGF-C was higher in pancreatic cancer, and VEGF-C was correlated with lymph node metastasis. VEGF-C was the biomarker that independently predicted disease-free survival after surgery for pancreatic cancer.
