CAJ | 학술논문

背景心肌标志物的正确应用为临床准确诊断、鉴别心血管疾病和判断治疗效果起到了革命性的作用,目前已经有越来越多的心肌损伤标志物在临床中得到应用,现对心型脂肪酸结合蛋白(heart-type fatty acid-binding protein,H-FABP)的研究相关进展作一综述.目的了解H-FABP的理化性质和临床检测方法,认识H-FABP在早期心肌梗塞诊断中的独特优势.内容结合国内外文献对H-FABP的基础和临床研究现状进行了阐述,对目前临床检测的方法进行了介绍,并对发展的趋势做了进一步展望.趋向随着H-FABP测定方法的不断改进及临床研究的不断深入,H-FABP正逐渐成为诊断心肌损伤的重要生化标志物.
배경 심기표지물적정학응용위림상준학진단、감별심혈관질병화판단치료효과기도료혁명성적작용,목전이경유월래월다적심기손상표지물재림상중득도응용,현대심형지방산결합단백(heart-type fatty acid-binding protein,H-FABP)적연구상관진전작일종술.목적 료해H-FABP적이화성질화림상검측방법,인식H-FABP재조기심기경새진단중적독특우세.내용 결합국내외문헌대H-FABP적기출화림상연구현상진행료천술,대목전림상검측적방법진행료개소,병대발전적추세주료진일보전망.추향 수착H-FABP측정방법적불단개진급림상연구적불단심입,H-FABP정축점성위진단심기손상적중요생화표지물.
Background The correct application of cardiac markers have played a revolutionary role for clinical accurate diagnosis,identification and treatment of cardiovascular disease. Now more and more cardiac biochemical markers have been applied in clinic researches,and the latest research progress in the field of H-FABP is reviewed in this paper.Objective To understand the physical and chemical properties and clinical detection methods of H-FABP,to recognize the unique advantages in diagnosis of the early AMI.Content To survey the basic and clinical research of H-FABP by reviewing domestic and international literatures, and to introduce the current clinical detection methods.Trend With the development of H-FABP determination methods and clinical research,H-FABP is becoming an important biochemical marker of myocardial injury.