广西师范学院学报：自然科学版
廣西師範學院學報：自然科學版
엄서사범학원학보：자연과학판
Journal of Guangxi Teachers Education University:Natural Science Edition
2011年
4期
46-50
,共5页
姚秋翠%黄燕敏%林启福%刘亮%崔建国
姚鞦翠%黃燕敏%林啟福%劉亮%崔建國
요추취%황연민%림계복%류량%최건국
睾酮%3-氮杂-A-homo-4a-雄烯-4-酮化合物%合成%抗肿瘤活性
睪酮%3-氮雜-A-homo-4a-雄烯-4-酮化閤物%閤成%抗腫瘤活性
고동%3-담잡-A-homo-4a-웅희-4-동화합물%합성%항종류활성
testosterone%3-aza-A-homo-4a-androstene-4-one%anactivities%synthesis
当在甾体化合物中引入氮原子或含氮官能团后,所得化合物的生物活性会明显提高。用酮经过酯化、肟化、重排、水解等反应合成3-氮杂-A-homo-4a-雄烯-4-酮化合物,并用六种人体肿瘤细胞珠对所合成化合物进行体外抗肿瘤活性的研究。
噹在甾體化閤物中引入氮原子或含氮官能糰後,所得化閤物的生物活性會明顯提高。用酮經過酯化、肟化、重排、水解等反應閤成3-氮雜-A-homo-4a-雄烯-4-酮化閤物,併用六種人體腫瘤細胞珠對所閤成化閤物進行體外抗腫瘤活性的研究。
당재치체화합물중인입담원자혹함담관능단후,소득화합물적생물활성회명현제고。용동경과지화、우화、중배、수해등반응합성3-담잡-A-homo-4a-웅희-4-동화합물,병용륙충인체종류세포주대소합성화합물진행체외항종류활성적연구。
The introduction of heteroatom or the replacement of one or more carbon atoms in steroidal molecule by a heteroatom will affect the chemical properties of the steroidal molecule and often result in alteration of its biological activity.3-aza-A-homo-4a-androstene-4-one were synthesized and the antiactivities of the compounds were studied.
