江西科学
江西科學
강서과학
JIANGXI SCIENCE
2011年
4期
477-479,524
,共4页
金雀异黄酮%刺芒柄花素%一锅法%合成
金雀異黃酮%刺芒柄花素%一鍋法%閤成
금작이황동%자망병화소%일과법%합성
Genistein%Formononetin%One-pot%Synthesis
以多羟基酚与对位取代的苯乙酸为原料,探究在BF3.Et2O作溶剂和催化剂中,天然活性物质金雀异黄酮和刺芒柄花素的合成方法及较优合成条件,结果表明金雀异黄酮不宜采用一锅法制备,刺芒柄花素在BF3.Et2O-DMF-PC l5体系用一锅法能取得较好的收率。
以多羥基酚與對位取代的苯乙痠為原料,探究在BF3.Et2O作溶劑和催化劑中,天然活性物質金雀異黃酮和刺芒柄花素的閤成方法及較優閤成條件,結果錶明金雀異黃酮不宜採用一鍋法製備,刺芒柄花素在BF3.Et2O-DMF-PC l5體繫用一鍋法能取得較好的收率。
이다간기분여대위취대적분을산위원료,탐구재BF3.Et2O작용제화최화제중,천연활성물질금작이황동화자망병화소적합성방법급교우합성조건,결과표명금작이황동불의채용일과법제비,자망병화소재BF3.Et2O-DMF-PC l5체계용일과법능취득교호적수솔。
The synthesis method and optimization of reaction conditions of genistein and formononetin were studied, using polyhydroxy phenol and p-substitutod phenylaeetic acid as material, BF3 · Et2O as solvent and catalyst. The result indicated that genistein is not suitable to produce by one-pot, while formononetin can be prepared in good yield in the system of BF3 · Et2O-DMF-PCl5 by one pot.
