中国临床营养杂志
中國臨床營養雜誌
중국림상영양잡지
CHINESE JOURNAL OF CLINICAL NUTRITION
2001年
1期
35-38
,共4页
冠心病%口服脂肪负荷试验%餐后血脂%过氧化脂质
冠心病%口服脂肪負荷試驗%餐後血脂%過氧化脂質
관심병%구복지방부하시험%찬후혈지%과양화지질
目的探讨冠心病患者餐后血脂代谢情况。方法对11例冠心病患者(冠心病组)和15例健康者(对照组)予低脂饮食2周后进食脂肪餐。于餐前、餐后2、4、6、8 h采血，检测血TG、TC、LDL-C、HDL-C、LPO及LDL-C的氧化活性LPO-LDL-C。结果冠心病组餐前TG（P<0.001）、LDL-C（P<0.01）极显著高于对照组，HDL-C（P<0.001）极显著低于对照组，LPO（P<0.001）、LDL-LPO-C（P<0.01）均极显著高于对照组。冠心病组餐后各点TG（P<0.01）极显著高于对照组，HDL-C（P<0.001）极显著低于对照组，LPO（P<0.001）、LDL-LPO-C（P<0.001）极显著高于对照组。多元回归分析表明餐后血脂（TG-AUC）与冠心病发生密切相关。冠心病组餐后8h的TG值（P<0.005）显著高于餐前，餐后各时段LDL-LPO-C（P<0.001）极显著高于餐前，对照组餐后各时段LDL-LPO-C（P<0.001）极显著高于餐前。结论冠心病患者存在餐后高血脂，餐后高血脂与冠心病发生密切相关，冠心病患者餐后LDL-C代谢异常，对氧化剂敏感性增强，脂质过氧化物明显增加。
目的探討冠心病患者餐後血脂代謝情況。方法對11例冠心病患者(冠心病組)和15例健康者(對照組)予低脂飲食2週後進食脂肪餐。于餐前、餐後2、4、6、8 h採血，檢測血TG、TC、LDL-C、HDL-C、LPO及LDL-C的氧化活性LPO-LDL-C。結果冠心病組餐前TG（P<0.001）、LDL-C（P<0.01）極顯著高于對照組，HDL-C（P<0.001）極顯著低于對照組，LPO（P<0.001）、LDL-LPO-C（P<0.01）均極顯著高于對照組。冠心病組餐後各點TG（P<0.01）極顯著高于對照組，HDL-C（P<0.001）極顯著低于對照組，LPO（P<0.001）、LDL-LPO-C（P<0.001）極顯著高于對照組。多元迴歸分析錶明餐後血脂（TG-AUC）與冠心病髮生密切相關。冠心病組餐後8h的TG值（P<0.005）顯著高于餐前，餐後各時段LDL-LPO-C（P<0.001）極顯著高于餐前，對照組餐後各時段LDL-LPO-C（P<0.001）極顯著高于餐前。結論冠心病患者存在餐後高血脂，餐後高血脂與冠心病髮生密切相關，冠心病患者餐後LDL-C代謝異常，對氧化劑敏感性增彊，脂質過氧化物明顯增加。
목적탐토관심병환자찬후혈지대사정황。방법대11례관심병환자(관심병조)화15례건강자(대조조)여저지음식2주후진식지방찬。우찬전、찬후2、4、6、8 h채혈，검측혈TG、TC、LDL-C、HDL-C、LPO급LDL-C적양화활성LPO-LDL-C。결과관심병조찬전TG（P<0.001）、LDL-C（P<0.01）겁현저고우대조조，HDL-C（P<0.001）겁현저저우대조조，LPO（P<0.001）、LDL-LPO-C（P<0.01）균겁현저고우대조조。관심병조찬후각점TG（P<0.01）겁현저고우대조조，HDL-C（P<0.001）겁현저저우대조조，LPO（P<0.001）、LDL-LPO-C（P<0.001）겁현저고우대조조。다원회귀분석표명찬후혈지（TG-AUC）여관심병발생밀절상관。관심병조찬후8h적TG치（P<0.005）현저고우찬전，찬후각시단LDL-LPO-C（P<0.001）겁현저고우찬전，대조조찬후각시단LDL-LPO-C（P<0.001）겁현저고우찬전。결론관심병환자존재찬후고혈지，찬후고혈지여관심병발생밀절상관，관심병환자찬후LDL-C대사이상，대양화제민감성증강，지질과양화물명현증가。
Objective To study the postprandial lipid metabolism in patients with coronary heart disease. Methods 11 CHD cases as CHD group and 15 normal as control group were selected to undergo oral fat load test. Blood samples were obtained before test and 2，4,6 and 8 hours after test. Serum TG, TC, LDL-C,HDL-C, LPO and LDL-LPO-C were calculated. Results 1.Preprandial TG, LDL-C, LPO and LDL-LPO-C in CHD group were significantly higher than that of control group. 2. Postprandial TG, LPO, LDL-LPO-C in CHD group were significantly higher than that of control group. Postprandial HDL-C in CHD group were significantly lower than control group. 3. Postprandial TG (8h), LDL-LPO-C in CHD group were significantly higher than in the preprandial. Postprandial LDL-LPO-C in control group was significantly higher than preprandial. Conclusions 1. Postprandial high-lipemia and dyslipemia was obvious in CHD group. 2. Postprandial high-lipemia was closely related to the development of CHD. 3. Postprandial LDL-LPO-C in CHD group increased significantly and LDL-C sensitivity to oxidative intensified with postprandial time. 4. Postprandial LPO in CHD group increased significantly.
