CAJ | 학술논문

聚乙二醇是一种常见的水溶性高分子,其水凝胶低毒,生物相容性好,广泛应用于生物医学和药学材料;PEG分子链的末端为活泼性基团-羟基,很容易发生化学反应得到聚乙二醇功能单体,利用这种大分子单体很容易制备出结构和性能各异的水凝胶;而且其分子量的应用范围很宽(从几百到几万).因此利用PEG为基体制备水凝胶具有独特的优势.此外,聚乙二醇基水凝胶以其众多的刺激响应功能显示出了广阔的应用前景,引起了人们的广泛关注.本文综述了近年来聚乙二醇基水凝胶研究方面的进展,包括水凝胶的合成、结构与性能的关系等,并特别强调了点击化学与超分子化学在水凝胶的设计与合成方面的重要性.
취을이순시일충상견적수용성고분자,기수응효저독,생물상용성호,엄범응용우생물의학화약학재료;PEG분자련적말단위활발성기단-간기,흔용역발생화학반응득도취을이순공능단체,이용저충대분자단체흔용역제비출결구화성능각이적수응효;이차기분자량적응용범위흔관(종궤백도궤만).인차이용PEG위기체제비수응효구유독특적우세.차외,취을이순기수응효이기음다적자격향응공능현시출료엄활적응용전경,인기료인문적엄범관주.본문종술료근년래취을이순기수응효연구방면적진전,포괄수응효적합성、결구여성능적관계등,병특별강조료점격화학여초분자화학재수응효적설계여합성방면적중요성.
Polyethylene glycol(PEG)was an ordinary water-soluble polymer. The hydrogel of PEG was widely applied in biomedicine because of low toxicity and good biocompatibility;The end groups of PEG molecule were hydroxyl,which was active,and functional macro-monomer was prepared easily. With these macro-monomer,hydrogel with different structure-properties could be obtained. Moreover,the molecular weight of PEG applied ranged widely (from hundreds to tens thousands) .It was convenient for the preparation of hydrogel via PEG. Much attention has been paid to the study of PEG hydrogels with multi-functions of stimulate-response. The progress of PEG-based hydrogel,including preparation and structure-properties,were reviewed and the importance of click chemistry and supramolecular chemistry is highlighted in this paper.