CAJ | 학술논문

目的:评价文拉法辛与帕罗西汀治疗紧张型头痛共患焦虑或抑郁的疗效及不良反应.方法:将符合ICHD-II诊断标准的35例共患焦虑或抑郁状态的紧张型头痛门诊患者随机分为两组,分别给予文拉法辛(n=18)75mg和帕罗西汀(n=17)20mg,疗程8周.用视觉模拟量表(VAS)、汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评定疗效并观察两组的不良反应.结果:文拉法辛组1例服药后头痛加重停药,帕罗西汀组1例头痛加重停药、1例不能忍受副反应改服其它药物.治疗后2、4、8周两组VAS、HAMD、HAMA评分无统计学意义,但治疗前后以上指标两组均有显著差异.结论:文拉法辛和帕罗西汀在治疗紧张型头痛共患焦虑、抑郁时安全有效,不良反应少.
목적:평개문랍법신여파라서정치료긴장형두통공환초필혹억욱적료효급불량반응.방법:장부합ICHD-II진단표준적35례공환초필혹억욱상태적긴장형두통문진환자수궤분위량조,분별급여문랍법신(n=18)75mg화파라서정(n=17)20mg,료정8주.용시각모의량표(VAS)、한밀이돈억욱량표(HAMD)、한밀이돈초필량표(HAMA)평정료효병관찰량조적불량반응.결과:문랍법신조1례복약후두통가중정약,파라서정조1례두통가중정약、1례불능인수부반응개복기타약물.치료후2、4、8주량조VAS、HAMD、HAMA평분무통계학의의,단치료전후이상지표량조균유현저차이.결론:문랍법신화파라서정재치료긴장형두통공환초필、억욱시안전유효,불량반응소.
Objective:To estimate the curative effect and adverse reactions of venlafaxine and paroxetine for treatment of tension-type headache accompanying anxiety or depression.Methods:35 patients were randomly divided into group 1 (treated with venlafaxine,75mg /d,n = 18) and group 2(treated with paroxetine,20mg/d,n = 17) according to ICHD-II criteria of tension-type headache accompanying anxiety or depression.The course of treatment was 8 weeks.VAS,HAMD,HAMA were used to assess the efficacy and adverse reactions.Results:Venlafaxine group; 1 case lost because of headache aggravated after medication,2 in Paroxetine group.The scores of VAS,HAMD,HAMA between group 1 and group 2 on the time points of 2,4,8 weeks end of post-treatment were no significant difference,but the above 3 observed indexes on pre-treatment and post-treatment were reached significant differences.Conclusions:Venlafaxine and paroxetine were effective and safe for the treatment of tension-type headhace accompanying anxiety or depression.