CAJ | 학술논문

目的:建立镇静安神类中成药及保健食品中非法添加的地西泮等14种化学成分的薄层色谱快速检测方法.方法:样品经甲醇提取后点于硅胶GF254薄层板上;以二氯甲烷-甲苯-丙酮-甲醇(8:8:3:1)为展开剂,检测地西泮等10种苯并二氮杂卓类添加成分:以正庚烷-甲苯-丙酮-三乙胺(6:5:4:1)为展开剂,检测巴比妥等4种巴比妥类添加成分;展开后置紫外光灯(254 nm)下检视.结果:在选定的色谱条件下,14种化学成分能得到较好的分离.结论:本法快速、简便、可作为镇静安神类中成药及保健食品中非法添加地西泮等14种化学成分的快速筛查方法.
목적:건립진정안신류중성약급보건식품중비법첨가적지서반등14충화학성분적박층색보쾌속검측방법.방법:양품경갑순제취후점우규효GF254박층판상;이이록갑완-갑분-병동-갑순(8:8:3:1)위전개제,검측지서반등10충분병이담잡탁류첨가성분:이정경완-갑분-병동-삼을알(6:5:4:1)위전개제,검측파비타등4충파비타류첨가성분;전개후치자외광등(254 nm)하검시.결과:재선정적색보조건하,14충화학성분능득도교호적분리.결론:본법쾌속、간편、가작위진정안신류중성약급보건식품중비법첨가지서반등14충화학성분적쾌속사사방법.
Objective:To establish a TLC method for detection of 14 sedative-hypnotic drugs in traditional Chinese medicines and health foods. Methods:Use silica gel GF254 as the coating substanee,dichloromethane-toluene-acetone-methanol (8:8:3:1) as the mobile phase system Ⅰ to detect 10 barbiturates and n-beptane-tnlucne-acetone-triethylamine (6:5:4:1) as the mobile phase system Ⅱ to detect 4 benzodiazepines. Results:At the selected chromatographic conditions,14 kinds of chemical constituents could get a better separation. Conclusion:The method is convenient, rapid, exclusive and can be employed to the fast detection of sedative-hypnotic drugs in traditional Chinese medicines and health foods.