中国实用医药
中國實用醫藥
중국실용의약
CHINA PRACTICAL MEDICAL
2009年
19期
46-47
,共2页
黄河%熊远清%唐碧莲%汤慧丽
黃河%熊遠清%唐碧蓮%湯慧麗
황하%웅원청%당벽련%탕혜려
缺氧缺血性脑病%神经元特异性烯醇化酶%新生儿
缺氧缺血性腦病%神經元特異性烯醇化酶%新生兒
결양결혈성뇌병%신경원특이성희순화매%신생인
Hypoxic-ischemic encephalopathy (HIE)%Neuon-specific enolase (NSE)%Newborn
目的 研究新生儿窒息后发生脑损伤与血清神经元特异性烯醇化酶(NSE)动态水平变化以及与新生儿HIE的关系.方法 实验组为新生儿病房Apgar评分≤3分的新生儿 38 例,生后观察临产表现及CT检查,结果 判断组轻度HIE 8 例,中度17 例,重度13 例,并以10例正常足月新生儿做为对照,采用放射免疫分析法,检测生后1、3天天血清NSE水平.结果 轻、中、重度组分别与对照组有显著差异(P<0.01).轻、中、重度HIE组之间3天内血清NSE比较,有显著差异(P<0.01).结论 血清NSE水平与HIE的病情严重程度相关,可作为早期诊断中、重度新生儿缺氧缺血性脑病的客观指标.
目的 研究新生兒窒息後髮生腦損傷與血清神經元特異性烯醇化酶(NSE)動態水平變化以及與新生兒HIE的關繫.方法 實驗組為新生兒病房Apgar評分≤3分的新生兒 38 例,生後觀察臨產錶現及CT檢查,結果 判斷組輕度HIE 8 例,中度17 例,重度13 例,併以10例正常足月新生兒做為對照,採用放射免疫分析法,檢測生後1、3天天血清NSE水平.結果 輕、中、重度組分彆與對照組有顯著差異(P<0.01).輕、中、重度HIE組之間3天內血清NSE比較,有顯著差異(P<0.01).結論 血清NSE水平與HIE的病情嚴重程度相關,可作為早期診斷中、重度新生兒缺氧缺血性腦病的客觀指標.
목적 연구신생인질식후발생뇌손상여혈청신경원특이성희순화매(NSE)동태수평변화이급여신생인HIE적관계.방법 실험조위신생인병방Apgar평분≤3분적신생인 38 례,생후관찰임산표현급CT검사,결과 판단조경도HIE 8 례,중도17 례,중도13 례,병이10례정상족월신생인주위대조,채용방사면역분석법,검측생후1、3천천혈청NSE수평.결과 경、중、중도조분별여대조조유현저차이(P<0.01).경、중、중도HIE조지간3천내혈청NSE비교,유현저차이(P<0.01).결론 혈청NSE수평여HIE적병정엄중정도상관,가작위조기진단중、중도신생인결양결혈성뇌병적객관지표.
Objective To study the changes of Neuron-specific enolase (NSE)in blood of newborns with Hypoxic ischemic encephalopathy and to make out the relationship between the level of NSE in cord blood and the brain damage after neonatal asphyxia. Methods Radioimmunoassay measured serm levels of NSE in postnatal 1,3 days of control group and test group. 10 normal newborns were control group. There were 38 neonates which Apgar score ≤3 server as the test group. Results The results showed that the level of NSE in cord blood of neonates with HIE was significantly higher than normal control(P<0.01).Conclusion The levels of NSE in cord blood are the symbol reflecting the early brain damage.
