CAJ | 학술논문

目的：通过监测肾移植后患者环孢素A(CsA)全血浓度，提出CsA在三联免疫抑制用药方案中的理想治疗窗。方法：用特异性荧光偏振免疫法测定CsA全血浓度，对406例患者监测2013例次。按术后时间及临床表现分组比较。结果：CsA在肾移植后＜1月、1月～＜3月、3月～＜6月、6月～＜12月、1年～＜2年和2年以上的理想治疗窗应分别为，250 μg*L-1～450 μg*L-1，200 μg*L-1～350 μg*L-1，180 μg*L-1～300 μg*L-1，100 μg*L-1～200 μg*L-1，100 μg*L-1～160 μg*L-1和90 μg*L-1～150 μg*L-1。结论：将CsA全血浓度调整到推荐治疗窗内，毒性反应和排异反应明显减少。
목적：통과감측신이식후환자배포소A(CsA)전혈농도，제출CsA재삼련면역억제용약방안중적이상치료창。방법：용특이성형광편진면역법측정CsA전혈농도，대406례환자감측2013례차。안술후시간급림상표현분조비교。결과：CsA재신이식후＜1월、1월～＜3월、3월～＜6월、6월～＜12월、1년～＜2년화2년이상적이상치료창응분별위，250 μg*L-1～450 μg*L-1，200 μg*L-1～350 μg*L-1，180 μg*L-1～300 μg*L-1，100 μg*L-1～200 μg*L-1，100 μg*L-1～160 μg*L-1화90 μg*L-1～150 μg*L-1。결론：장CsA전혈농도조정도추천치료창내，독성반응화배이반응명현감소。
To monitor the whole blood trough concentration of cyclosporine A (CsA) in renal transplant recipients and establish an optimal therapeutic window of CsA. METHOD: A total 2013 samples from 406 renal transplant recipients were measured by specific fluorescence polarization immunoassay. According to the time after operation and clinical symptoms, the whole blood trough concentration was compared in subgroups. RESULTS: The optimal therapeutic window of CsA was 250 μg*L-1～450 μg*L-1 (less than 1 month after operation), 200 μg*L-1～350 μg*L-1 (1 months～＜3 months), 180 μg*L-1～300 μg*L-1 (3 months～＜6 months), 100 μg*L-1～200 μg*L-1 (6 months～＜12 months), 100 μg*L-1～160 μg*L-1 (1 years～＜2 years), 90 μg*L-1～150 μg*L-1(more than 2 years), respectivily. CONCLUSION: The incidence of toxic effects and rejection reaction will be obviously diminished if the whole blood levels of CsA were adjusted to the therapeutic and safe range.