遗传
遺傳
유전
HEREDITAS(BEIJING)
2001年
2期
161-166
,共6页
神经管缺陷%基因表达%基因突变
神經管缺陷%基因錶達%基因突變
신경관결함%기인표체%기인돌변
神经管缺陷是中枢神经系统最常见的先天畸形，许多种类基因的表达或突变与神经系统发育、神经管缺陷有关，它们是：（1）发育调节基因及转录因子类基因。（2）原癌基因和抑癌基因。（3）生长因子及其受体基因。（4）蛋白激酶C相关基因。（5）同型半胱氨酸代谢相关基因。（6）其他基因：细胞骨架类、细胞连接类基因等。
神經管缺陷是中樞神經繫統最常見的先天畸形，許多種類基因的錶達或突變與神經繫統髮育、神經管缺陷有關，它們是：（1）髮育調節基因及轉錄因子類基因。（2）原癌基因和抑癌基因。（3）生長因子及其受體基因。（4）蛋白激酶C相關基因。（5）同型半胱氨痠代謝相關基因。（6）其他基因：細胞骨架類、細胞連接類基因等。
신경관결함시중추신경계통최상견적선천기형，허다충류기인적표체혹돌변여신경계통발육、신경관결함유관，타문시：（1）발육조절기인급전록인자류기인。（2）원암기인화억암기인。（3）생장인자급기수체기인。（4）단백격매C상관기인。（5）동형반광안산대사상관기인。（6）기타기인：세포골가류、세포련접류기인등。
Neural tube defects are common congenital abnormalities of the central nervous system.Expression or mutation of many types of genes have been found to exhibit an especially correlation with the neurulation and neural tube defects.They are: (1)development regulation genes and transcription factors genes, (2)oncogenes and tumor supressor genes, (3)growth factors genes and their receptors genes, (4)protein kinase C related genes, (5)homocysteine metabolism related genes, (6)and others, such as cytoskeleton and cell junction genes.
