CAJ | 학술논문

目的:研究3种鼠(小白鼠A、草原兔尾鼠B、子午沙鼠C）对戊肝病毒（HEV）的反应。方法：检查疫区捕获的小林姬鼠；对人工饲养繁殖后的B、C鼠实验感染HEV：第1次用已证实含HEV*RNA的人粪便悬液攻击A、B、C3种鼠；第2次用已感染HEV的小林姬鼠和B鼠肝组织攻击，观察各种反应。结果：第1次攻击后临床表现少而轻，仅20％B鼠出现精神萎靡，A、B、C鼠全部有酶血症，C鼠排毒HCV*RNA＋占25％，肝组织普遍有病理反应（占30％～100％）。感染后死亡仅见B鼠（占50％）。结论：实验用3种鼠均可感染HEV，应重视其在传播中的作用，并可从中筛选动物模型。
목적:연구3충서(소백서A、초원토미서B、자오사서C）대무간병독（HEV）적반응。방법：검사역구포획적소림희서；대인공사양번식후적B、C서실험감염HEV：제1차용이증실함HEV*RNA적인분편현액공격A、B、C3충서；제2차용이감염HEV적소림희서화B서간조직공격，관찰각충반응。결과：제1차공격후림상표현소이경，부20％B서출현정신위미，A、B、C서전부유매혈증，C서배독HCV*RNA＋점25％，간조직보편유병리반응（점30％～100％）。감염후사망부견B서（점50％）。결론：실험용3충서균가감염HEV，응중시기재전파중적작용，병가종중사선동물모형。
Objective: Studying the reactions for HEV on mice(A),Laguruslagurus(B),and Meriones meridianus(C). Methods:Check up Apodemus sylvaticus captured in HEV epidemic area,infect with HEV B and C bred in the laboratory.In the first time, animals A,B and C were injected by the suspension liquid of the dejecta of patient,who has been confirrmed to be infected HEVRNA.In the second time, the rodents were injected by the suspension liquid of the liver of Apodemus sylvaticus and B.It was observed for the clinical characters of all test animals. Result:The clinical characters of the rodents were light but only 20% of B was dispirited and inert and died to 50% after injected in the first time,there were special blood-enxyme characters in all animals.25% of C was found to be positive for HEVRNA.There was pathological reactions in liver tissues (from 30% to 100%). Conclusions: All three species can be infected by HEV,in which laboratory animal model for HEV can be sifted from the species. We must pay attention to their disease spreading function.