第二军医大学学报
第二軍醫大學學報
제이군의대학학보
ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY
2001年
1期
57-60
,共4页
丁厚中%杨海人%蔡晓凤%李良波%李才华%吴晓阳%杨栋%冷新%倪灿荣%朱明华%李海
丁厚中%楊海人%蔡曉鳳%李良波%李纔華%吳曉暘%楊棟%冷新%倪燦榮%硃明華%李海
정후중%양해인%채효봉%리량파%리재화%오효양%양동%랭신%예찬영%주명화%리해
胃肿瘤%癌基因蛋白质,P33ING1%癌基因蛋白质,P5 3
胃腫瘤%癌基因蛋白質,P33ING1%癌基因蛋白質,P5 3
위종류%암기인단백질,P33ING1%암기인단백질,P5 3
目的：探讨P33ING1表达在 胃癌发生、发展过程中的病理生物学及临床意义。方法: 应用免疫组 化EnVision法,分别检测了原发性胃癌（71例）、胃粘膜不典型增生（12例）、正常胃粘膜 或慢性胃炎粘膜（18例）组织中P33ING1的表达，以及P53和Bcl-2在胃癌组织中的表 达情况。结果:胃粘膜不典型增生组及对照组（正常胃粘膜或慢性胃炎 粘膜）P33ING1均呈阳性表达，胃癌组织P33ING1表达率仅为62.0%(44/71),显 著低于前两组（P<0.01)。胃癌组织中P33ING1表达与肿瘤的浸润、淋巴结的转 移 及分化有关（P<0.01)；P53表达与肿瘤大小、浸润、淋巴结转移有关（P<0.01)；B cl-2与肿瘤的淋巴结转移及分化有关（P<0.05）。P33ING1与P53在胃癌组织中 的表达有相关性（P<0.05），与Bcl-2则无相关性。结论:P33 ING1在胃癌组织中表达下降，对胃癌发生、发展可能起重要作用。同时检测P33ING 1与P53的表达水平，对于原发性胃癌的诊断和治疗可能具有积极意义。
目的：探討P33ING1錶達在 胃癌髮生、髮展過程中的病理生物學及臨床意義。方法: 應用免疫組 化EnVision法,分彆檢測瞭原髮性胃癌（71例）、胃粘膜不典型增生（12例）、正常胃粘膜 或慢性胃炎粘膜（18例）組織中P33ING1的錶達，以及P53和Bcl-2在胃癌組織中的錶 達情況。結果:胃粘膜不典型增生組及對照組（正常胃粘膜或慢性胃炎 粘膜）P33ING1均呈暘性錶達，胃癌組織P33ING1錶達率僅為62.0%(44/71),顯 著低于前兩組（P<0.01)。胃癌組織中P33ING1錶達與腫瘤的浸潤、淋巴結的轉 移 及分化有關（P<0.01)；P53錶達與腫瘤大小、浸潤、淋巴結轉移有關（P<0.01)；B cl-2與腫瘤的淋巴結轉移及分化有關（P<0.05）。P33ING1與P53在胃癌組織中 的錶達有相關性（P<0.05），與Bcl-2則無相關性。結論:P33 ING1在胃癌組織中錶達下降，對胃癌髮生、髮展可能起重要作用。同時檢測P33ING 1與P53的錶達水平，對于原髮性胃癌的診斷和治療可能具有積極意義。
목적：탐토P33ING1표체재 위암발생、발전과정중적병리생물학급림상의의。방법: 응용면역조 화EnVision법,분별검측료원발성위암（71례）、위점막불전형증생（12례）、정상위점막 혹만성위염점막（18례）조직중P33ING1적표체，이급P53화Bcl-2재위암조직중적표 체정황。결과:위점막불전형증생조급대조조（정상위점막혹만성위염 점막）P33ING1균정양성표체，위암조직P33ING1표체솔부위62.0%(44/71),현 저저우전량조（P<0.01)。위암조직중P33ING1표체여종류적침윤、림파결적전 이 급분화유관（P<0.01)；P53표체여종류대소、침윤、림파결전이유관（P<0.01)；B cl-2여종류적림파결전이급분화유관（P<0.05）。P33ING1여P53재위암조직중 적표체유상관성（P<0.05），여Bcl-2칙무상관성。결론:P33 ING1재위암조직중표체하강，대위암발생、발전가능기중요작용。동시검측P33ING 1여P53적표체수평，대우원발성위암적진단화치료가능구유적겁의의。
Objective:To discuss the pathological relationship between P33ING1 and stomach cancer and its clinical significance. Methods: In 71 cases of stomach cancer specimen, twelve cases of gas tric mu cous membrane atypical hyperplasia tissues and 18 cases of normal gastric mucous membrane tissue（as control）,the expression of P33ING1 were detected b y EnVision immunohistochemical method,while the expression of P53 and Bcl -2 in stomach cancer were also detected. Results: P33IN G1 expression in mucous membrane atypical hyperplasia group and control group was positive, the expression in stomach cancer group was extremely low(62.0%，44 /71), significantly different from the other 2 groups(P<0.01).P33ING1 expression in stomach cancer was related to the tumor growth, lymph node meta s tasis and tumor polarization (P<0.01), P53 expression was related to tumor s ize, growth and lymph node metastasis (P<0.01). Bcl-2 expression was relate d to lymph node metatasis and tumor polarization.The expression of P33ING1 was related to that of P53 in stomach cancer(P<0.05),while had no relation with that of Bcl-2.Conclusion:P33ING1 may play an importa nt role in the occurrance and development of stomach cancer.It's very important to detect the expression of P33ING1 and P53 simultaneously.
