CAJ | 학술논문

目的：从血液流变学角度探讨中药治疗子宫内膜异位症的作用机制以及丹那唑不良反应的产生机制。方法：造模成功后，将大鼠分为空白组、模型组、西药组和中药组，灌胃给药1个月，然后取血，各组间进行血液流变性比较。结果：丹那唑显著影响实验性大鼠模型的血液流变性，产生高粘滞状态，而中药无该不良反应。结论：丹那唑治疗子宫内膜异位症所产生的不良反应与其对血液流变性的影响有一定的关系，而中药可改善血液的高粘滞状态，中西医结合治疗子宫内膜异位症可提高疗效，减少不良反应。
목적：종혈액류변학각도탐토중약치료자궁내막이위증적작용궤제이급단나서불량반응적산생궤제。방법：조모성공후，장대서분위공백조、모형조、서약조화중약조，관위급약1개월，연후취혈，각조간진행혈액류변성비교。결과：단나서현저영향실험성대서모형적혈액류변성，산생고점체상태，이중약무해불량반응。결론：단나서치료자궁내막이위증소산생적불량반응여기대혈액류변성적영향유일정적관계，이중약가개선혈액적고점체상태，중서의결합치료자궁내막이위증가제고료효，감소불량반응。
Objective：To explore the mechanism of treatment of endometriosis with Chinese drugs and the mechanism of adverse effects caused by danazol on blood rheology level.Method:Autologus endometrial segments were implanted in the peritoneum of rats,making experimental animal model.Rats were divided into four groups randomly:Control group,Model control group,Danazol group and Herb group,treated with normal saline,normal saline,Danazol and herb decoction respectively for one month.The effects of Chinese drugs and danazol on blood rheology of experimental rats were compared.Result:This experiment has shown that side effects of danazol might relate to its effect on blood rheology.Chinese drugs promoting blood circulation can improve hyperviscosity Syndrome.Conclusion:Endometriosis could be treated with western medicine combined with Chinese medicine,which can increase curative effect and decrease side effects.