CAJ | 학술논문

目的：观察三黄肾康丸对腺嘌呤致大鼠慢性肾衰（CRF）的影响。方法：连续喂养0.75％腺嘌呤使Wister大鼠产生类似于人慢性肾衰的症状。2周后，治疗组大鼠每天用中药三黄肾康丸（12.0g/kg、6.0g/kg）灌胃，连续6周，并于第4、8周测定大鼠血尿素氮（BUN）、肌酐（Scr）、RBC、HGB、HCT及肾脏病理学检查。结果：三黄肾康丸明显改善大鼠肾衰的症状，与模型组大鼠比较，肾重量减轻（P<0.01），纤维化程度降低，肾组织内结晶沉积物减少。结论：三黄肾康丸对大鼠肾衰有明显治疗效果。
목적：관찰삼황신강환대선표령치대서만성신쇠（CRF）적영향。방법：련속위양0.75％선표령사Wister대서산생유사우인만성신쇠적증상。2주후，치료조대서매천용중약삼황신강환（12.0g/kg、6.0g/kg）관위，련속6주，병우제4、8주측정대서혈뇨소담（BUN）、기항（Scr）、RBC、HGB、HCT급신장병이학검사。결과：삼황신강환명현개선대서신쇠적증상，여모형조대서비교，신중량감경（P<0.01），섬유화정도강저，신조직내결정침적물감소。결론：삼황신강환대대서신쇠유명현치료효과。
OBJECTIVE： To observe the effects of SHSK on chronic renalfailure(CRF)in rats induced by adenine.METHODS： A rat model of renal failure,induced by feeding fodder containing 0.75％ adenine,could manifest signs resembling those observed in man with CRF.After two weeks of adenine feeding,SHSK in a dose of 12.0g/(kg· d) or 6.0g/(kg· d) was given to the rats for six weeks.At the 4th and 8th weeks,the BUN,Scr,RBC,HGB and HCT were detected and the pathalogy of the kidney was examined.RESULTS： The results indicated that SHSK given orally could improve the signs in rats with CRF.In comparison with the untreated control group,the kidney weight was lightened(P<0.01),crystals in renal tissue decreased and the proliferation of fibroid tissue was alleviated.CONCLUSION： SHSK has a markedly therapeutic effect on renal failure in rats.