CAJ | 학술논문

1997年发现的内吗啡肽（Endomorphins、EMs），结构上属于四肽，被认为是μ阿片受体（MOR）的内源性配基，它通过与G蛋白偶联的MOR受体结合介导许多生理活动，本文结合本实验室对内吗啡肽的研究，对其神经系统分布、受体结合特性、生理作用、构象及构效关系等方面进行介绍。
1997년발현적내마배태（Endomorphins、EMs），결구상속우사태，피인위시μ아편수체（MOR）적내원성배기，타통과여G단백우련적MOR수체결합개도허다생리활동，본문결합본실험실대내마배태적연구，대기신경계통분포、수체결합특성、생리작용、구상급구효관계등방면진행개소。
Endomorphins(EMs),two tetrapeptides, were discovered in 1997 and believed to be endogenous ligands of μ-opioide receptor(MOR). They mediated various physiological processes by binding to MOR that couple with G-proteins. Based on our works and literatures, we reviewed the distribution in nerve system, receptor binding properties, analgesis, effects on ion channels, conformation and struction-activity relationship of EMs.