临床与实验病理学杂志
臨床與實驗病理學雜誌
림상여실험병이학잡지
CHINESE JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
2001年
1期
26-27
,共2页
欧阳永娥%郑锦阳%庄建良%许荣誉%陈文斌
歐暘永娥%鄭錦暘%莊建良%許榮譽%陳文斌
구양영아%정금양%장건량%허영예%진문빈
乳腺肿瘤%灌注,局部%细胞凋亡
乳腺腫瘤%灌註,跼部%細胞凋亡
유선종류%관주,국부%세포조망
目的:探讨术前动脉灌注化疗诱导乳腺癌细胞凋亡发生情况及其对患者预后的影响。方法:分别采用TUNEL法检测及电镜观察术前动脉灌注化疗40例和术前未化疗的42例晚期乳腺癌细胞凋亡发生情况,计算凋亡发生率及凋亡指数,并进行对比分析。结果:术前动脉灌注化疗组与术前未化疗组凋亡发生率分别为92.5%和78.5%,凋亡指数分别为19.37±6.49和9.26±5.04(P<0.01)。凋亡指数高低与局部晚期乳腺癌的无病生存率相关(P<0.01)。结论:局部晚期乳腺癌术前动脉灌注化疗可诱导乳腺癌细胞的凋亡,提高患者无病生存率。
目的:探討術前動脈灌註化療誘導乳腺癌細胞凋亡髮生情況及其對患者預後的影響。方法:分彆採用TUNEL法檢測及電鏡觀察術前動脈灌註化療40例和術前未化療的42例晚期乳腺癌細胞凋亡髮生情況,計算凋亡髮生率及凋亡指數,併進行對比分析。結果:術前動脈灌註化療組與術前未化療組凋亡髮生率分彆為92.5%和78.5%,凋亡指數分彆為19.37±6.49和9.26±5.04(P<0.01)。凋亡指數高低與跼部晚期乳腺癌的無病生存率相關(P<0.01)。結論:跼部晚期乳腺癌術前動脈灌註化療可誘導乳腺癌細胞的凋亡,提高患者無病生存率。
목적:탐토술전동맥관주화료유도유선암세포조망발생정황급기대환자예후적영향。방법:분별채용TUNEL법검측급전경관찰술전동맥관주화료40례화술전미화료적42례만기유선암세포조망발생정황,계산조망발생솔급조망지수,병진행대비분석。결과:술전동맥관주화료조여술전미화료조조망발생솔분별위92.5%화78.5%,조망지수분별위19.37±6.49화9.26±5.04(P<0.01)。조망지수고저여국부만기유선암적무병생존솔상관(P<0.01)。결론:국부만기유선암술전동맥관주화료가유도유선암세포적조망,제고환자무병생존솔。
To determine the effect of pre-operative chemotherapy on apoptosis in breast cancer and to evaluate its signif icance as a prcgnostic marker. Methods Patients with breast cancer were divided into preoperative chemotherapy group (40 cases)and control group (42 cases). Two groups were analyzed for the appearance of apoptosis by using TUNEL method and electron mi croscope in tissue sections. Results Apoptosis occurred in 92.5 % of preoperative chemotherapy group and in 78.5 % of control group. The apoptotic indexes were 19.37 + 6.49 and 9.26 + 5.04 ( P < 0.01 ) respectively. Low apoptotic index was related to disease-free survival of patients with breast cancer (P < 0.01 ). Conclusion The preoperative chemotherapy can induce apoptcsis of breast cancer and improve disease-free survival.