CAJ | 학술논문

观察Xanthone(XT)对小鼠反复脑缺血再灌流后行为学的影响。将40只小鼠分为4组，经反复脑缺血再灌流加降血压法造模后，分别给予注射用水、XT静脉注射高剂量50mg/kg和低剂量10mg/kg，术后进行跳台、水迷宫实验测试。结果显示，模型组小鼠潜伏期缩短，游全程时间延长、错误次数增多；XT高、低二个剂量组均使上述指标改善，有显著性差异。揭示XT可对抗反复脑缺血再灌流后行为学的障碍，学习记忆力的下降。
관찰Xanthone(XT)대소서반복뇌결혈재관류후행위학적영향。장40지소서분위4조，경반복뇌결혈재관류가강혈압법조모후，분별급여주사용수、XT정맥주사고제량50mg/kg화저제량10mg/kg，술후진행도태、수미궁실험측시。결과현시，모형조소서잠복기축단，유전정시간연장、착오차수증다；XT고、저이개제량조균사상술지표개선，유현저성차이。게시XT가대항반복뇌결혈재관류후행위학적장애，학습기억력적하강。
40 mice models with vascular dementia(VD)were devided into 4groups and administered respectively with injecting water,XT(10mg/kg,50mg/kg,iv).Observe their behaviors in step-down avoidance test and water-maze test.Results:The mouse's performance in the water labyrinth was obviously affected.The whole distance swimming time was prolonged and mistakes increased.XT can improve the above incidence and there was remarkable difference in statistics.It proved that XT could strengthen the mouse in earning and memory.