CAJ | 학술논문

目的：探讨非小细胞肺癌中cyclinA的表达与细胞增殖活性及预后的关系。方法：采用免疫组化法检测cyclinA在60例非小细胞肺癌中的表达，采用流式细胞术分析DNA含量。结果：在非小细胞肺癌中cyclinA的阳性率为48.3％(29/60)，cyclinA阳性者的S期细胞比例[(14.4±3.9)％]明显高于阴性者[(9.4±3.5)％]，cyclinA的表达与患者预后有关。结论：cyclinA的表达与肿瘤细胞增殖活性增高密切相关，是判断非小细胞肺癌患者预后的一个可参考指标。
목적：탐토비소세포폐암중cyclinA적표체여세포증식활성급예후적관계。방법：채용면역조화법검측cyclinA재60례비소세포폐암중적표체，채용류식세포술분석DNA함량。결과：재비소세포폐암중cyclinA적양성솔위48.3％(29/60)，cyclinA양성자적S기세포비례[(14.4±3.9)％]명현고우음성자[(9.4±3.5)％]，cyclinA적표체여환자예후유관。결론：cyclinA적표체여종류세포증식활성증고밀절상관，시판단비소세포폐암환자예후적일개가삼고지표。
Objective： The current study was designed to investigate the relationship between cyclin A expression in non-small cell lung carcinoma (NSCLC) and the proliferative activity and the prognosis. Methods： Cyclin A expression in 60 non-small cell lung carcinoma specimens was detected by immunohistochemical method. DNA content was measured by flow cytometry. Results： Twenty-nine cases (48.3％ ) showed cyclin A expression. The median S-phase fraction of the cyclin A-positive 14.4± 3.9％ was higher than that of the cyclin A-negative 9.4± 3.5％ . The overall survival was significantly lower in patients with cyclin A expression than in those without cyclin A expression. Conclusion： Cyclin A expression contributed to the high proliferative activity in non-small cell lung carcinoma cells. Cyclin A might be a prognostic marker of non-small cell lung carcinoma.