中国科学C辑(英文版)
中國科學C輯(英文版)
중국과학C집(영문판)
SCIENCE IN CHINA (Series C)
2002年
3期
225-236
,共12页
魏青青%程晓阳%陈克樱%胡钧%李民乾%朱培闳
魏青青%程曉暘%陳剋櫻%鬍鈞%李民乾%硃培閎
위청청%정효양%진극앵%호균%리민건%주배굉
ryanodine receptor/calcium release channel%atomic force microscope%elasticity
Atomic force microscope was applied to investigate the effect of extrinsic phospholipid on the structure of rabbit skeletal muscle ryanodine receptor/calcium release channel (RyR1). In addition, in the presence of extrinsic phospholipid, the height and elasticity of the RyR1s in different functional states were also measured. The results indicate: (i) most of the RyR1s showed a normal structure only in the presence of extrinsic phospholipid; (ii) treatment of the RyR1s with AMP and Ca2+ together could increase their Young's Modulus but not change their apparent height; (iii) no detectable change in either height or Young's Modulus of the RyR1s appeared, if the RyR1s were treated with other activators or inhibitors.
