CAJ | 학술논문

目的探讨非典型鳞状上皮细胞(ASC)的临床意义及其进一步处理方法.方法对348例宫颈细胞学检查诊断为ASC的患者行阴道镜下多点活检术,同时采用荧光定量PCR法检测HPV DNA含量.结果组织活检CIN Ⅰ～Ⅲ85例,炎症263例;HPV DNA阳性84例、阴性264例.高危型HPV DNA阳性标本中CINⅡ～Ⅲ的检出率明显高于HPV阴性标本(P<0.01),高危型HPV DNA的阴性预测值为99.0%.结论 ASC患者应联合检测HPV,高危型HPV DNA阳性者应直接行阴道镜活检,进一步明确诊断.高危型HPV DNA检测对宫颈CIN有更好的预测价值.
목적 탐토비전형린상상피세포(ASC)적림상의의급기진일보처리방법.방법 대348례궁경세포학검사진단위ASC적환자행음도경하다점활검술,동시채용형광정량PCR법검측HPV DNA함량.결과 조직활검CIN Ⅰ～Ⅲ85례,염증263례;HPV DNA양성84례、음성264례.고위형HPV DNA양성표본중CINⅡ～Ⅲ적검출솔명현고우HPV음성표본(P<0.01),고위형HPV DNA적음성예측치위99.0%.결론 ASC환자응연합검측HPV,고위형HPV DNA양성자응직접행음도경활검,진일보명학진단.고위형HPV DNA검측대궁경CIN유경호적예측개치.
Objective To explore the clinical significance of atypical squamous cells (ASC) and the further dealing method. Methods Multipoint biopsies under colposcope was applied to the 348 patients. At the same time,the content of HPV-DNA detected with FQ-PCR. Results Totally 85 cases among them were CIN Ⅰ-Ⅲ, 263 cases were determined as imflammation, 84 cases were determined as HPV-DNA-positive, and 264 cases were HPV-DNA negative. Compared with that of the specimens with HPV negative, CIN Ⅰ-Ⅲ detection rate of the specimens of HPV-DNA with high risk was significantly higher (P<0. 01). The negativen predictive value of high-risk type HPV-DNA was 99. 0%. Conclusion The patients with HPV-DNA positive should receive biopsies under colposcope so as to acquire final diagnosis. It is necessary for patients with ASC to receive HPV-DNA detection. Detection of HPV-DNA with high risk may have more forecasting value to cervical intra-epithelial neoplasia (CIN).