CAJ | 학술논문

支气管哮喘(简称哮喘)是伴有细胞因子产生异常及气道内变态反应性炎症发生的一种免疫失衡性疾病.多种信号转导通路参与哮喘的发病机制,分别介导着细胞因子、炎性介质和黏附因子在哮喘发病中的作用.其中JAK/STAT6信号转导通路是哮喘发病中的重要信号转导通路之一,该通路与哮喘发病的多种病理基础相关,IL-4、IL- 13等细胞介质可激活JAK/STAT6通路.研究该信号转导通路对哮喘的治疗具有重要意义.本文就JAK/STAT6信号转导通路的特点及其与哮喘的关系作一综述.
지기관효천(간칭효천)시반유세포인자산생이상급기도내변태반응성염증발생적일충면역실형성질병.다충신호전도통로삼여효천적발병궤제,분별개도착세포인자、염성개질화점부인자재효천발병중적작용.기중JAK/STAT6신호전도통로시효천발병중적중요신호전도통로지일,해통로여효천발병적다충병리기출상관,IL-4、IL- 13등세포개질가격활JAK/STAT6통로.연구해신호전도통로대효천적치료구유중요의의.본문취JAK/STAT6신호전도통로적특점급기여효천적관계작일종술.
Bronchial asthma (asthma) is an immune imbalance disease associated with abnormal cytokine production and allergic inflammation of airway.There are many signal transduction systems which regulate respectively with the role of variety of cytokines,inflammatory mediators and adhesion molecules in the body.JAK/STAT6 pathway which is related to many pathological mechanisms is one of the most important signal transduction pathways.The upstream of IL -4,IL-13 is stimulatory factors in the pathogenesis of asthma.There is great significance of the study of JAK/STAT6 pathway for the treatment of asthma.The JAK/STAT6 signal transduction pathway and its relationship with asthma is reviewed in this paper.