中华肾脏病杂志
中華腎髒病雜誌
중화신장병잡지
2011年
4期
243-246
,共4页
张伟明%蒋更如%钱家麒%王炳顺%朱淳%王咏梅%黄海东%严玉澄%倪兆慧
張偉明%蔣更如%錢傢麒%王炳順%硃淳%王詠梅%黃海東%嚴玉澄%倪兆慧
장위명%장경여%전가기%왕병순%주순%왕영매%황해동%엄옥징%예조혜
血液透析%治疗结果%设备安全%聚醚砜透析器%聚砜膜透析器
血液透析%治療結果%設備安全%聚醚砜透析器%聚砜膜透析器
혈액투석%치료결과%설비안전%취미풍투석기%취풍막투석기
Hemodialysis%Treatment outcome%Equipment safety%Polyethersulfone dialyzer%Polyesulfone dialyzer
目的 评价国产PES14LF聚醚砜低通量透析器对维持性血液透析(MHD)患者的疗效和安全性.方法 选择上海两家医院72例MHD患者为研究对象,进行随机平行对照试验.试验组采用国产PES14LF透析器,对照组采用德国F6聚砜膜透析器.检测透析器尿素、肌酐、磷清除率和下降比率,以及试验前后实验室指标.观察及记录不良反应.结果 两组间尿素、肌酐清除率差异均无统计学意义.试验组磷清除率显著大于对照组[(144.57±27.83)ml/min比(117.15±22.77)ml/min,P＜0.051.试验组尿素下降比率大于65%.两组间尿素、肌酐、磷下降比率差异均无统计学意义.两组间尿素清除有效率和尿素下降比有效率差异均无统计学意义.两组治疗前后实验室评价指标均无明显变化,不良事件少而程度轻,无不良反应.结论 国产PES14LF聚醚砜低通量透析器临床使用安全、有效.
目的 評價國產PES14LF聚醚砜低通量透析器對維持性血液透析(MHD)患者的療效和安全性.方法 選擇上海兩傢醫院72例MHD患者為研究對象,進行隨機平行對照試驗.試驗組採用國產PES14LF透析器,對照組採用德國F6聚砜膜透析器.檢測透析器尿素、肌酐、燐清除率和下降比率,以及試驗前後實驗室指標.觀察及記錄不良反應.結果 兩組間尿素、肌酐清除率差異均無統計學意義.試驗組燐清除率顯著大于對照組[(144.57±27.83)ml/min比(117.15±22.77)ml/min,P＜0.051.試驗組尿素下降比率大于65%.兩組間尿素、肌酐、燐下降比率差異均無統計學意義.兩組間尿素清除有效率和尿素下降比有效率差異均無統計學意義.兩組治療前後實驗室評價指標均無明顯變化,不良事件少而程度輕,無不良反應.結論 國產PES14LF聚醚砜低通量透析器臨床使用安全、有效.
목적 평개국산PES14LF취미풍저통량투석기대유지성혈액투석(MHD)환자적료효화안전성.방법 선택상해량가의원72례MHD환자위연구대상,진행수궤평행대조시험.시험조채용국산PES14LF투석기,대조조채용덕국F6취풍막투석기.검측투석기뇨소、기항、린청제솔화하강비솔,이급시험전후실험실지표.관찰급기록불량반응.결과 량조간뇨소、기항청제솔차이균무통계학의의.시험조린청제솔현저대우대조조[(144.57±27.83)ml/min비(117.15±22.77)ml/min,P＜0.051.시험조뇨소하강비솔대우65%.량조간뇨소、기항、린하강비솔차이균무통계학의의.량조간뇨소청제유효솔화뇨소하강비유효솔차이균무통계학의의.량조치료전후실험실평개지표균무명현변화,불량사건소이정도경,무불량반응.결론 국산PES14LF취미풍저통량투석기림상사용안전、유효.
Objective To evaluate the efficacy and safety of PES14LF polyethersulfone highflux dialyzer on maintenance hemodialysis(MHD)patients. Methods A total of 72 MHD patients from two hospitals in Shanghai were enrolled in a randomized parallel controlled study.Conventional hemodialysis was performed for 4 h with PES14LF dialyzer in trial group and with German F6 dialyzer in control group.For each patient the study lasted one week.The clearances of urea,creatinine and phosphate were calculated.Adverse event and adverse reaction were recorded.Results There were no significant difierences of urea and creatinine clearance and reduction ratio between trial and control group.The phosphate clearance in trial group was significantly higher than that in control group[(144.57±27.83)ml/min vs(117.15±22.77)ml/min,P＜0.051.There was no significant difference of phosphate reduction ratio between trial and control group.The efficiency of urea clearance and urea reduction ratio achieved clinic effective target in two groups and no significant differences in above indexes between two groups were found. Conclusion PES14LF dialyzer is effective and safe for clinical application.
