中华手外科杂志
中華手外科雜誌
중화수외과잡지
CHINESE JOURNAL OF HAND SURGERY
2012年
1期
5-8
,共4页
王猛%徐文东%邱彦群%华续赟%蒋苏%徐建光
王猛%徐文東%邱彥群%華續赟%蔣囌%徐建光
왕맹%서문동%구언군%화속빈%장소%서건광
神经移位%动物,实验%脑功能重组%上肢运动功能障碍
神經移位%動物,實驗%腦功能重組%上肢運動功能障礙
신경이위%동물,실험%뇌공능중조%상지운동공능장애
Nerve transfer%Animals,laboratory%Brain reorganization%Upper extremity motor dysfunction
目的 研究成年大鼠健侧颈7(C7)神经移位治疗中枢神经损伤后一侧上肢感觉运动功能障碍的可行性.方法 取清洁级雌性SD大鼠24只,随机分成3组,即健康对照组(n=8)；脑外伤模型组(n=8)；脑外伤+健侧颈7神经根移位至瘫痪侧颈7神经根组(n=8).分别于术前、术后2周、4周、6周、8周、3个月、5个月、7个月、10个月、12个月,采用抓取实验、肢体不对称实验等动物行为学方法,评价大鼠瘫痪上肢损伤程度及功能恢复情况.结果 术后行为学结果显示,术后不同时间各实验组大鼠瘫痪上肢功能均有一定程度的自发性恢复.术后3个月健侧颈7神经移位组大鼠瘫痪上肢功能优于脑外伤模型组.术后7个月,各实验组大鼠瘫痪肢体功能恢复趋于稳定,三组比较差异有统计学意义,C组优于B组.结论 健侧颈7移位术治疗中枢神经损伤上肢功能障碍是可行、有效的.
目的 研究成年大鼠健側頸7(C7)神經移位治療中樞神經損傷後一側上肢感覺運動功能障礙的可行性.方法 取清潔級雌性SD大鼠24隻,隨機分成3組,即健康對照組(n=8)；腦外傷模型組(n=8)；腦外傷+健側頸7神經根移位至癱瘓側頸7神經根組(n=8).分彆于術前、術後2週、4週、6週、8週、3箇月、5箇月、7箇月、10箇月、12箇月,採用抓取實驗、肢體不對稱實驗等動物行為學方法,評價大鼠癱瘓上肢損傷程度及功能恢複情況.結果 術後行為學結果顯示,術後不同時間各實驗組大鼠癱瘓上肢功能均有一定程度的自髮性恢複.術後3箇月健側頸7神經移位組大鼠癱瘓上肢功能優于腦外傷模型組.術後7箇月,各實驗組大鼠癱瘓肢體功能恢複趨于穩定,三組比較差異有統計學意義,C組優于B組.結論 健側頸7移位術治療中樞神經損傷上肢功能障礙是可行、有效的.
목적 연구성년대서건측경7(C7)신경이위치료중추신경손상후일측상지감각운동공능장애적가행성.방법 취청길급자성SD대서24지,수궤분성3조,즉건강대조조(n=8)；뇌외상모형조(n=8)；뇌외상+건측경7신경근이위지탄탄측경7신경근조(n=8).분별우술전、술후2주、4주、6주、8주、3개월、5개월、7개월、10개월、12개월,채용조취실험、지체불대칭실험등동물행위학방법,평개대서탄탄상지손상정도급공능회복정황.결과 술후행위학결과현시,술후불동시간각실험조대서탄탄상지공능균유일정정도적자발성회복.술후3개월건측경7신경이위조대서탄탄상지공능우우뇌외상모형조.술후7개월,각실험조대서탄탄지체공능회복추우은정,삼조비교차이유통계학의의,C조우우B조.결론 건측경7이위술치료중추신경손상상지공능장애시가행、유효적.
Objective To investigate the feasibility of treating dysfunction in the forearm following central nervous system injury using contralateral C7 nerve transfer in rodent models.Methods Twenty-four female Sprague Dawley(SD)rats were studied.They were randomly divided into three groups:(A)the normal control group(n =8);(B)the group with a unilateral(left)motor cortex aspiration(n =8);(C)the group with a unilateral(left)motor cortex aspiration and contralateral(left)C7 nerve transfer to the paralyzed(right)side(n =8).The extent of injury and functional recovery of the paralyzed upper limb was evaluated preoperatively and 2,4,6,8 weeks and 3,5,7,10,12 months postoperatively using behavioral tests such as skilled reaching task and limb-use asymmetry test.Results All the rats in the two experimental groups showed spontaneous functional improvement postoperatively.By 3 months after the operation,the transferred contralateral C7 nerve reached the target muscles and the rats began to demonstrate superior functional recovery to the animals with unilateral(left)motor cortex aspiration only.At the end of 7 months postoperatively,the motor recovery of the paralyzed forearm plateaued.There were significant differences among the three groups(P ＜ 0.01),while Group C revealed significantly better results comparing to Group B.Conclusion Contralateral C7 nerve transfer is an effective method for the treatment of forearm dysfunction following central nervous system injury in rats.
