CAJ | 학술논문

目的研究表皮生长因子受体(EGFR)与雌孕激素受体(ER、PR)在宫颈癌中的相关性及其在预后中的意义,探讨检测此种受体作为判断宫颈癌生物学形为的可行性.方法应用免疫组化法对65例宫颈癌的石蜡切片组织中ERGF与ER、PR含量进行检测分析并追踪随访.结果 EGFR总的阳性率为58.5%(38/65),在高分化、低分化,未分化癌中其阳性率分别为42.8(15/35)、74.0(18/24)、83.3%(5/6)(P<0.01)与肿瘤的大小、临床分期及年龄组无关,与ER、PR之间存在着明显负相关.全组平均随访时间60个月,EGFR阳性组术后生存率明显低于阴性组.结论检测EGFR与ER、PR在宫颈癌中的表达可作为判断其生物学行为的一个很有用的指标.
목적 연구표피생장인자수체(EGFR)여자잉격소수체(ER、PR)재궁경암중적상관성급기재예후중적의의,탐토검측차충수체작위판단궁경암생물학형위적가행성.방법 응용면역조화법대65례궁경암적석사절편조직중ERGF여ER、PR함량진행검측분석병추종수방.결과 EGFR총적양성솔위58.5%(38/65),재고분화、저분화,미분화암중기양성솔분별위42.8(15/35)、74.0(18/24)、83.3%(5/6)(P<0.01)여종류적대소、림상분기급년령조무관,여ER、PR지간존재착명현부상관.전조평균수방시간60개월,EGFR양성조술후생존솔명현저우음성조.결론 검측EGFR여ER、PR재궁경암중적표체가작위판단기생물학행위적일개흔유용적지표.
Objective To Probe the epidermis growth factor receptor (EGFR) and estrogen receptor(ER) and progesterone re-ceptor(PR) as the judge possible of cervical cancer biological behavior. Methods EGFR and ER. PR of cervical adnocarcinoma were analysed by immunity chemical method in paraffin embed tissue in 65 cases and trace visit. Results The positive rates of EG-FR were 58. 5% (38/65). In Carcinoma of poor differentiation, high differentiation and anaplastic, positive rates EGFR was 41.9%(15/43), 74.0% (18/24),83.3% (5/6) respectively The between EGFR and ER, PR were negatively correlated (P < 0.05). It were not related to tumor size,stage of the disease or age of the patients. The average follow -up of patients were 60 months. The o-verall survival was significantly worse for patients with EGFR - positive tumors compared with EGFR - negative tumors. Conclusion Expression of EGFR and ER PR was tested in cervical cancer as a target significant to judge it biological behavior.