CAJ | 학술논문

目的评价国产和进口丙泊酚(力蒙欣/得普利麻)的临床麻醉效果及市场价格差异.方法拟行无痛人工流产患者60例,将其随机分为两组,力蒙欣组(L组)和得普利麻组(D组),每组30例.入室患者开放上肢静脉,静脉注射舒芬太尼0.1 μg/kg后,靶控输注丙泊酚血浆浓度4μg/ml.L组输注1％力蒙欣(批号:0908281西安力邦生物制药有限公司),D组输注1％得普利麻(批号:GG244 AstraZeneca公司意大利).警觉与镇静评分(OAA/S)评分≤1,脑电双频指数(BIS)＜ 60时开始手术,术中维持BIS 40 ～ 60.术中连续监测血压(Bp)、心电图(ECG)、脉搏血氧饱和度(SpO2)和BIS,每60秒对患者进行OAA/S,记录手术时间、丙泊酚用量、丙泊酚靶控输注时间、麻醉起效时间、唤醒时间和唤醒时BIS值、指令反应时间、BIS＞ 70、术中知晓、遗忘和各种并发症及不良反应.结果与麻醉前比较,注药后1 min时和手术开始时两组平均血压(MBp)下降(P＜0.05),心率(HR)呈下降趋势.BIS明显下降(P＜0.05)并持续至术毕,清醒后回升,但仍低于基础值.BIS和血压变化两组间比较差异无统计学意义(P＞0.05).两组手术时间,丙泊酚用量,麻醉用药时间、麻醉起效时间、唤醒时间和唤醒时BIS值、指令反应时间和BIS＞ 70比较差异无统计学意义(P＞0.05).两组患者麻醉效果评级及注射痛情况比较差异无统计学意义(P＞0.05),D组呼吸抑制(6/2例)和呼吸暂停(6/1例)发生率高于L组,D组出现术后遗忘1例.进口丙泊酚的药价是国产丙泊酚的1.2倍.结论力蒙欣和得普利麻用于短时快通道麻醉(无痛人工流产术),麻醉效果和安全性差异无统计学意义,力蒙欣的效-价比优于得普利麻.
목적 평개국산화진구병박분(력몽흔/득보리마)적림상마취효과급시장개격차이.방법 의행무통인공유산환자60례,장기수궤분위량조,력몽흔조(L조)화득보리마조(D조),매조30례.입실환자개방상지정맥,정맥주사서분태니0.1 μg/kg후,파공수주병박분혈장농도4μg/ml.L조수주1％력몽흔(비호:0908281서안력방생물제약유한공사),D조수주1％득보리마(비호:GG244 AstraZeneca공사의대리).경각여진정평분(OAA/S)평분≤1,뇌전쌍빈지수(BIS)＜ 60시개시수술,술중유지BIS 40 ～ 60.술중련속감측혈압(Bp)、심전도(ECG)、맥박혈양포화도(SpO2)화BIS,매60초대환자진행OAA/S,기록수술시간、병박분용량、병박분파공수주시간、마취기효시간、환성시간화환성시BIS치、지령반응시간、BIS＞ 70、술중지효、유망화각충병발증급불량반응.결과 여마취전비교,주약후1 min시화수술개시시량조평균혈압(MBp)하강(P＜0.05),심솔(HR)정하강추세.BIS명현하강(P＜0.05)병지속지술필,청성후회승,단잉저우기출치.BIS화혈압변화량조간비교차이무통계학의의(P＞0.05).량조수술시간,병박분용량,마취용약시간、마취기효시간、환성시간화환성시BIS치、지령반응시간화BIS＞ 70비교차이무통계학의의(P＞0.05).량조환자마취효과평급급주사통정황비교차이무통계학의의(P＞0.05),D조호흡억제(6/2례)화호흡잠정(6/1례)발생솔고우L조,D조출현술후유망1례.진구병박분적약개시국산병박분적1.2배.결론 력몽흔화득보리마용우단시쾌통도마취(무통인공유산술),마취효과화안전성차이무통계학의의,력몽흔적효-개비우우득보리마.
Objective To evaluate the clinical anesthesia effects and market price distinction between domestic propofol and imported propofol ( Limengxin / Diprivan).Methods Sixty patients undergoing painless artificial abortion were randomly divided into two groups:Limengxin group (group L) and Diprivan group (group D),30 cases for each group.The two groups received intravenous infusion of sufentanil at 0.1 μg/kg. The patients received propofol (group L:1％ Limengxin and group D:1％ Diprivan) by target controlled infusion (TCI) at a target effect site concentration(Ce) of 4 μg/ml.The surgery began when BIS ＜ 60,and it was needed to maintain BIS 40-60.During the operations,Bp,ECG,SpO2 and BIS were continuously monitored.OAA/S was made to patients every 60 seconds,and operation time,propofol dosage,propofol TCI time,onset time,arousal time and arousal BIS value,instructions response time,BIS ＞ 70 time,awareness in operation,amnesia,various complications and adverse effects were recorded.Results The mBP was decreased after anesthesia in both groups at 1 minute after the start of propofol TCI and when the operations began.The HR presented decrease tendency.BIS was significantly decreased (P ＜ 0.05 ) until to the operations ended,and it was increased after the patients awaked,but it was lower than that before anesthesia.There were no significant difference in BIS and BP between the two groups (P ＞ 0.05 ).There were no significant difference in operation time,propofol dosage,medication time,onset time,arousal time and arousal BIS value,instructions response time,BIS ＞ 70time between the two groups ( P ＞ 0.05).There were also no significant difference in the rank of anesthesia effects and the state of infusion pains between the two groups (P ＞ 0.05).The incidence rate of respiratory depression (6:2) and breathing holding (6:1) in group D was higher than that in group L.There was one patient who had postoperative amnesia in group D. The price of importedpropofol was 1.2 times that of domestic propofol.Conclusions There were no significant difference in anesthesia effects and safeve between domestic propofol and imported propofol (Limengxin / Diprivan)when they were used in the anesthesia of painless artificial abortion.