CAJ | 학술논문

Objective To establish animal model for hypertreophic scar and study the characteristics of its morphology and collagen metabolism.Methods A total of 64 wounds(diameter of 6 mm each ) with total skin loss were made on the ventral side of rabbit ear using a trephine. Morphology and collagen metabolism of scar wound were studied at 14,21,35,70 and 98 days after operation,respectively.Results There were 76% elevated scars developed (45/59 wounds) on the ventral side of rabbit ear on 21st and 35 days.The number of fibroblast decreased,but irregular-arranged fibers still presented in the elevated scars at 70 and 98 days after operation. Hydroxyproline content in elevated scars at 21 days was higher than that in normal skin(P< 0.05),and at 35 days was 3 times as that in normal skin and at 98 days was also markedly higher than that in normal skin(P< 0.05).Conclusion Excessive deposition of collagen is a characteristic of hypertrophic scar in rabbits. The conversion of normal scarring to hypertrophic scarring in rabbits occurs at 14～ 21 days after operation. Both development and regression of hypertrophic scar in rabbit are quicker than that in human.