CAJ | 학술논문

内皮祖细胞在缺血组织的血管形成及损伤血管的内皮再生中起重要作用.细胞因子作为血管形成中微环境的重要组成,对内皮祖细胞的调控发挥重要作用,有效应用对内皮祖细胞发挥正性调控作用的细胞因子可明显提高内皮祖细胞的数量、生物学功能及其治疗效果.现就血管内皮生长因子等7种细胞因子对内皮祖细胞的调控机制进行综述.
내피조세포재결혈조직적혈관형성급손상혈관적내피재생중기중요작용.세포인자작위혈관형성중미배경적중요조성,대내피조세포적조공발휘중요작용,유효응용대내피조세포발휘정성조공작용적세포인자가명현제고내피조세포적수량、생물학공능급기치료효과.현취혈관내피생장인자등7충세포인자대내피조세포적조공궤제진행종술.
Endothelial progenitor cells play a significant role in neovascularization of ischemic tissues and in reendothelialization of damaged blood vessels. Cytokines, an important components of micro-environment of angiogenesis,play an important role in regulation of endothelial progenitor cells. The effective application of cytokines can significantly argument the number, enhance the biological function and improve the therapeutic effect of endothelial progenitor cells, which play a positive role in regulation of endothelial progenitor cells.This article briefly reviewed the regulating mechanisms of the vascular endothelial growth factor and other cytokines in a total of 7 endothelial progenitor cells.