CAJ | 학술논문

衣原体是重要的人类病原体,其能够导致多种疾病的发生.由衣原体引起的许多人类疾病被认为是免疫病理学介导的.已经证明Toll样受体(TLRs)是多种病原体感染的主要模式识别受体( PRRs),在起始固有免疫应答,建立适应性免疫应答中发挥着重要作用.在TLR家族中,TLR2和TLR4与衣原体感染的相关性研究备受关注,在识别衣原体感染、调节宿主的早期免疫应答、炎症反应和病理形成中执行着关键性的作用.研究TLR2和TLR4在免疫应答衣原体感染中的作用可以更好地理解TLRs介导的分子免疫机制,可能有助于研发免疫治疗的分子靶标,最终有效预防、控制衣原体感染引起的疾病.
의원체시중요적인류병원체,기능구도치다충질병적발생.유의원체인기적허다인류질병피인위시면역병이학개도적.이경증명Toll양수체(TLRs)시다충병원체감염적주요모식식별수체( PRRs),재기시고유면역응답,건립괄응성면역응답중발휘착중요작용.재TLR가족중,TLR2화TLR4여의원체감염적상관성연구비수관주,재식별의원체감염、조절숙주적조기면역응답、염증반응화병리형성중집행착관건성적작용.연구TLR2화TLR4재면역응답의원체감염중적작용가이경호지리해TLRs개도적분자면역궤제,가능유조우연발면역치료적분자파표,최종유효예방、공제의원체감염인기적질병.
Chlamydiae are important human pathogens and the leading causative agents for a variety of diseases.Many human diseases caused by chlamydiae are considered to be immunopathologically mediated.Toll like receptors (TLRs) have been proved as the major pattern recognition receptors (PRRs) for many pathogens.TLRs play an important role in the process of initiating innate immune response and establishing adaptive immune responses.Among TLR family,the roles of TLR2 and TLR4 have been extensively studied in chlamydial infection.TLR2 and TLR4 play essential roles for the recognition of chlamydial infection,regulation of the early immune responses and inflammatory reaction.In this article,the roles of TLR2 and TLR4 in immune responses to chlamydial infection were reviewed.A better understanding of the immunological and molecular mechanisms mediated by TLRs will help to explore the molecular targets for immunotherapy and ultimately to control the diseases infected by chlamydiae.