CAJ | 학술논문

目的探讨老年人阻塞性睡眠呼吸暂停综合征(OSAHS)与脑白质疏松(LA)之间的关系.方法对应用多导睡眠呼吸监测诊断的169例OSAHS患者进行头颅磁共振检查,评估LA的发生率及其程度,探讨睡眠呼吸参数与LA程度的关系.结果 169例OSAHS患者中无LA24例(14.20%);LA 145例(85.80%),其中轻度LA 27例(15.98%),中度LA 65例(38.46%),重度LA53例(31.36%).对不同程度LA患者年龄、体重指数及睡眠呼吸参数进行比较发现,年龄、睡眠呼吸紊乱指数(AHI)、平均血氧饱和度(MSaO2)、SaO2＜90%时间及氧减指数各组间差异有统计学意义(P＜0.05).经Logistic回归分析,年龄及氧减指数与LA密切相关.结论随着年龄的增加,氧减指数逐渐增大,LA发生率逐渐增加,程度逐步加重.对OSAHS患者采取适当的干预措施有利于改善LA引起的认知功能障碍等症状.
목적 탐토노년인조새성수면호흡잠정종합정(OSAHS)여뇌백질소송(LA)지간적관계.방법 대응용다도수면호흡감측진단적169례OSAHS환자진행두로자공진검사,평고LA적발생솔급기정도,탐토수면호흡삼수여LA정도적관계.결과 169례OSAHS환자중무LA24례(14.20%);LA 145례(85.80%),기중경도LA 27례(15.98%),중도LA 65례(38.46%),중도LA53례(31.36%).대불동정도LA환자년령、체중지수급수면호흡삼수진행비교발현,년령、수면호흡문란지수(AHI)、평균혈양포화도(MSaO2)、SaO2＜90%시간급양감지수각조간차이유통계학의의(P＜0.05).경Logistic회귀분석,년령급양감지수여LA밀절상관.결론 수착년령적증가,양감지수축점증대,LA발생솔축점증가,정도축보가중.대OSAHS환자채취괄당적간예조시유리우개선LA인기적인지공능장애등증상.
Objective To study the relationship between the leukoaraiosis (LA) and obstructive sleep apnea/hypopnea syndrome(OSAHS)in the elderly. Methods 169 cases of OSAHS diagnosed by polysomnogram (PSG) underwent brain MRI to evaluate the incidence and degree of LA and to explore the relationship between LA and OSAHS in the elderly. Results LA was found in 145 (85.80%) of 169 OSAHS cases, and rdmong them, mild LA in 27 cases (15.98%), moderate in 65 (38.46%) and severe in 53 (31.36%). There was a significant correlation of LA with age, oxygen desaturation index,MSaO2 sleep time spent when SaO2＜90%,apnea hyponea index(AHI)(P＜0.05).By multivariate regression analyses, age and oxygen desaturation index were the most vital effective factors for LA. Conclusions With the increase of patients'age and oxygen desaturation index,LA becomes more common and aggravated. Appropriate interventive treatment for OSAHS will be able to ameliorate the LA-induced cognitive dysfunction.