CAJ | 학술논문

目的探讨白介素-1受体拮抗剂(IL-Ra)基因多态性分布与2型糖尿病肾病的相关性. 方法应用聚合酶链反应-产物长度多态性检测87例2型糖尿病无肾病患者,78例2型糖尿病合并肾病患者和148名健康对照者的IL-1Rα第二内含子的86个碱基(bp)数目可变重复片段(VNTR)多态性. 结果 2型糖尿病无肾病患者等位基因A2及含A2基因型频率高于2型糖尿病合并肾病患者(P＜0.05). 结论 A2等位基因可能是糖尿病肾病发病的遗传因素之一.
목적탐토백개소-1수체길항제(IL-Ra)기인다태성분포여2형당뇨병신병적상관성. 방법응용취합매련반응-산물장도다태성검측87례2형당뇨병무신병환자,78례2형당뇨병합병신병환자화148명건강대조자적IL-1Rα제이내함자적86개감기(bp)수목가변중복편단(VNTR)다태성. 결과 2형당뇨병무신병환자등위기인A2급함A2기인형빈솔고우2형당뇨병합병신병환자(P＜0.05). 결론 A2등위기인가능시당뇨병신병발병적유전인소지일.
Objective To investigate the frequency of interleukin 1 receptor antagonist(IL Ra) gene polymorphism and its relationship to dibetic nephropathy. Methods The allele frequency and the genotype distribution of the polymorphism in second intron of IL Ra gene were studied in the groups of 148 non diabetic controls and 165 type 2 diabetes patients, with or without diabetic nephropathy. Results IL 1β and IL 1Rα frequencies were higher and IL 1Rα/IL 1β were lower in diabetes than those in control group.IL 1β was correlated with higher triglyceride, total cholesterol and fasting plasma glucose levels( P <0.05). The frequency of A 2 allele in control group was higher than those in all diabetic patients and patients with diabetic nephropathy group significantly ( P <0.05) but slightly higher than that in diabetic patients without diabetic nephropathy ( P >0.05). The frequency of A 2 allele in diabetic patients without diabetic nephropathy was higher than that in diabetic patients with diabetic nephropathy. Conclusion Diabetes patients with A 2 (240 bp allele) were less susceptible to diabetic nephropathy than those without A 2 allele.