CAJ | 학술논문

AP-2作为一个核转录因子家族,常以二聚体方式与特异的DNA序列结合,从而调节基因表达参与生长发育、细胞凋亡等重要生物学功能.病理状态下,AP-2能通过对细胞增殖和分化、细胞周期调控、细胞凋亡等各方面作用参与肿瘤的发生和发展.近年来,也有众多研究者寄希望以AP-2为靶点为临床治疗肿瘤提供新的思路.
AP-2작위일개핵전록인자가족,상이이취체방식여특이적DNA서렬결합,종이조절기인표체삼여생장발육、세포조망등중요생물학공능.병리상태하,AP-2능통과대세포증식화분화、세포주기조공、세포조망등각방면작용삼여종류적발생화발전.근년래,야유음다연구자기희망이AP-2위파점위림상치료종류제공신적사로.
AP-2,a nuclear transcription factor family,always binds to a typical DNA sequence in the dimer way,thus AP-2 can regulates the expression of many other genes and participate in the growth and devel-opment, apoptosis and many other physiological processes. Under pathological conditions, AP-2 also plays an im-portant role in tumor genesis and development by influencing cell proliferation, differentiation, cell cycle regula-tion and apoptosis. Recent years,many researchers want to find new therapeutic strategies that target AP-2 in a series of human cancers.