CAJ | 학술논문

目的研究腹腔免疫治疗对大肠癌术后腹腔局部复发和肝转移的疗效及安全性.方法 172例大肠癌根治术后患者,随机分为常规腹腔化疗组86例(对照组)和腹腔免疫治疗组86例(观察组);对照组应用氟尿嘧啶1.0 g、丝裂霉素8 mg进行腹腔灌注化疗,观察组在对照组的基础上加用白细胞介素-2治疗,观察两组治疗有效率及肿瘤复发情况.结果观察组有效率(70.9%)高于对照组(55.8%)(P＜0.05);观察组三年生存率(83.7%)、无瘤生存率(44.2%)高于对照组的62.8%、22.1%(P＜0.05);观察组三年复发率(25.6%)、及肝转移率(34.9%)低于对照组的37.8%、48.9%(P＜0.05);两组胃肠道反应、Ⅰ或Ⅱ度骨髓抑制、肝功能异常(谷丙转氨酶升高)发生率比较差异无统计学意义(P＞0.05).结论大肠癌根治术后进行早期腹腔免疫治疗,可有效地预防腹腔肿瘤局部复发和肝脏转移,提高生存率,值得临床推广应用.
목적 연구복강면역치료대대장암술후복강국부복발화간전이적료효급안전성.방법 172례대장암근치술후환자,수궤분위상규복강화료조86례(대조조)화복강면역치료조86례(관찰조);대조조응용불뇨밀정1.0 g、사렬매소8 mg진행복강관주화료,관찰조재대조조적기출상가용백세포개소-2치료,관찰량조치료유효솔급종류복발정황.결과 관찰조유효솔(70.9%)고우대조조(55.8%)(P＜0.05);관찰조삼년생존솔(83.7%)、무류생존솔(44.2%)고우대조조적62.8%、22.1%(P＜0.05);관찰조삼년복발솔(25.6%)、급간전이솔(34.9%)저우대조조적37.8%、48.9%(P＜0.05);량조위장도반응、Ⅰ혹Ⅱ도골수억제、간공능이상(곡병전안매승고)발생솔비교차이무통계학의의(P＞0.05).결론 대장암근치술후진행조기복강면역치료,가유효지예방복강종류국부복발화간장전이,제고생존솔,치득림상추엄응용.
Objective To Research the efficacy and side effects of intra-abdominal chemotherapy immune to the abdominal cavity after colorectal cancer liver metastasis and local recurrence.Methods 172 eases of colorectal cancer patients after radical operation were randomly divided into conventional regulation 86 cases of abdominal chemotherapy group(control group) and the immune abdominal chemotherapy group of 86 cases(observation group).The control group received 5-FU1.0,MMC8mg intraperitoneal chemotherapy The observation group at the grass-rcots level to add IL-2 50 million U.Results Observation group effective rate .was 70.9% higher than 55.8% (P ＜0.05) ;the obsenation gionp the three-year survival rate 83.7%,dlsease-free survival rate was 44.2% higher than the 62.8%,22.1% (P＜0.05) ;observation group three-year recurrence rate of 25.6% and 34.9% lower than the rate of liver metastases in the control group of 37.8%,48.9% (P＜0.05) ;two groups of gastrointestinal reaction,ⅠⅡ or degree of bone marrow suppression,liver function mildly abnormal ( elevated alanine amiuotransferase) had no difference.Conclusion For advanced colorectal cancer patients with early immune abdominal chemotherapy,the effective prevention and treatment of abdominal cavity and liver metastasis planting to improve the survival rate,side effects of light,fewer complications,the extension of survival,worthy of clinical application.