CAJ | 학술논문

Securin是垂体肿瘤转化基因编码的具有多种功能的蛋白,在有丝分裂中期向后期的过渡中负责调控姐妹染色单体的分离.Securin表达异常在多种内分泌腺体及腺体相关癌症被发现,如脑垂体瘤、甲状腺癌、卵巢癌、结肠癌等.Securin在这些癌症中的作用机制与其顺时转化作用及与其他癌症相关蛋白如p21、p53等有关.
Securin시수체종류전화기인편마적구유다충공능적단백,재유사분렬중기향후기적과도중부책조공저매염색단체적분리.Securin표체이상재다충내분비선체급선체상관암증피발현,여뇌수체류、갑상선암、란소암、결장암등.Securin재저사암증중적작용궤제여기순시전화작용급여기타암증상관단백여p21、p53등유관.
Securin is a multifunctional protein which is encoded by PTTG gene.In the metaphase to anaphase transition during mitosis,Securin is involved in sister chromatid separation.The aberrant expression of Securin is found in many endocrine and related cancers,such as pituitary tomour,thyroid cancer,ovarian cancer,colon cancer et al.The function of Securin in cancer is related to its gene transactivation and association with other poteins like p21,p53.