中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2009年
5期
38-39
,共2页
乙型肝炎病毒相关性肾炎%足细胞顶端膜蛋白%podocalyxin%拉米夫定%干预研究
乙型肝炎病毒相關性腎炎%足細胞頂耑膜蛋白%podocalyxin%拉米伕定%榦預研究
을형간염병독상관성신염%족세포정단막단백%podocalyxin%랍미부정%간예연구
HBV-associated glomerulonephritis%Podocyte apical membrane protein%Pedocalyxin%Podocalyxin%Intervention research
目的 探讨乙型肝炎病毒相关性肾炎(HBV-GN)足细胞顶端膜蛋白podoealyxin的改变及拉米夫定干预后的变化.方法 将67例HBV-GN患者作为观察组;60例健康查体者为对照组,观察尿中足细胞计数和podocalyxin(PCX)的改变及拉米夫定治疗后的变化.结果 67例不同病理类型患者尿中足细胞计数和PCX的含量均较对照组为高;与尿蛋白定量呈正相关;拉米夫定治疗后尿中足细胞计数和PCX的含量均较治疗前明显下降.结论 HBV-GN患者尿足细胞计数及PCX的变化与肾脏组织的损伤程度相关;通过拉米夫定的抗病毒治疗有利于损伤足细胞的修复;尿足细胞计数及尿PCX是反映肾组织病变的灵敏指标.
目的 探討乙型肝炎病毒相關性腎炎(HBV-GN)足細胞頂耑膜蛋白podoealyxin的改變及拉米伕定榦預後的變化.方法 將67例HBV-GN患者作為觀察組;60例健康查體者為對照組,觀察尿中足細胞計數和podocalyxin(PCX)的改變及拉米伕定治療後的變化.結果 67例不同病理類型患者尿中足細胞計數和PCX的含量均較對照組為高;與尿蛋白定量呈正相關;拉米伕定治療後尿中足細胞計數和PCX的含量均較治療前明顯下降.結論 HBV-GN患者尿足細胞計數及PCX的變化與腎髒組織的損傷程度相關;通過拉米伕定的抗病毒治療有利于損傷足細胞的脩複;尿足細胞計數及尿PCX是反映腎組織病變的靈敏指標.
목적 탐토을형간염병독상관성신염(HBV-GN)족세포정단막단백podoealyxin적개변급랍미부정간예후적변화.방법 장67례HBV-GN환자작위관찰조;60례건강사체자위대조조,관찰뇨중족세포계수화podocalyxin(PCX)적개변급랍미부정치료후적변화.결과 67례불동병리류형환자뇨중족세포계수화PCX적함량균교대조조위고;여뇨단백정량정정상관;랍미부정치료후뇨중족세포계수화PCX적함량균교치료전명현하강.결론 HBV-GN환자뇨족세포계수급PCX적변화여신장조직적손상정도상관;통과랍미부정적항병독치료유리우손상족세포적수복;뇨족세포계수급뇨PCX시반영신조직병변적령민지표.
Objective To observe the changes of the glomerular pedocyte apical membrane protein podocalyxin in patients with HBV-associated glomerulonephritis and the effect of intervention of Lamivudine.Methods To analyze the podocyte count and the expression of podocalyxin in the urine and changes after treat-ment of Lanivudine. The observation group consisted of 67 patients with HBV-associated glomerulonephritis and 60 persons who did health examination in the same time were used as control group. Results The podocyte count and the podocalyxin content in the observation group were higher than those in the control group and a positive correlation with urinary protein quantity; The podocyte count and the podocalyxin content descended ob-viously after treatment with Lamivudine. Conclusion There is a correlation between the podocyte count and the podocalyxin content of patients with HBV-associated glomerulonephritis and the extent of kidney damage; The antivirus therapy of Lamivudine benefits the repair of injured podocytes; The podocyte count and the podocalyxin content are sensitive indicators to the changes of nephropathy.
