辐射研究与辐射工艺学报
輻射研究與輻射工藝學報
복사연구여복사공예학보
JOURNAL OF RADIATION RESEARCH AND RADIATION PROCESSING
2001年
1期
65-66
,共2页
陆长元%韩镇辉%姚思德%林念芸
陸長元%韓鎮輝%姚思德%林唸蕓
륙장원%한진휘%요사덕%림념예
DNA%黄素腺嘌呤二核苷酸(FAD)%激光光解%鸟嘌呤阳离子自由基%定位损伤
DNA%黃素腺嘌呤二覈苷痠(FAD)%激光光解%鳥嘌呤暘離子自由基%定位損傷
DNA%황소선표령이핵감산(FAD)%격광광해%조표령양리자자유기%정위손상
The interaction of oxidized FAD radical with dGMP, dAMP and single-stranded DNA (ssDNA) was investigated in neutral aqueous solution using time-resolved 248 nm laser flash photolysis aimed at elucidation of the initial photosensitization mechanism. The characterized absorption spectra of transient species were observed. Moreover, direct observation of stabilized DNA guanyl radical has provided transient evidence for site-selective photosensitized damage of DNA at guanine moiety, which has simulated the major initial species produced by the direct effect of ionizing radiation or UV light on DNA.
