CAJ | 학술논문

目的:探讨自身免疫性中枢神经系统脱髓鞘疾病慢性型的病理特点及其临床意义.方法:建立猴实验性变应性脑脊髓炎(experimental allergic encephalomyelitis,EAE)模型,于首次发病后4年进行病理取材和电镜观察.结果:①活动性病灶内轴突病变十分突出.其形式包括有空泡样变性、皱缩或消失,此外也可见成片的髓鞘松解、断裂或融合,少突胶质细胞变性,以及散在的巨噬细胞.②可疑活动性病灶内轴突病变程度稍轻,以空泡变性为主,轴突完全消失及皱缩则少见,部分髓鞘与轴突的变性及散在的巨噬细胞.结论:慢性EAE的病理改变同时存在髓鞘与轴突的变性,多发性硬化(multipe sclerosis,MS)后期不可逆的功能障碍可能与后者有更大的相关.
목적:탐토자신면역성중추신경계통탈수초질병만성형적병리특점급기림상의의.방법:건립후실험성변응성뇌척수염(experimental allergic encephalomyelitis,EAE)모형,우수차발병후4년진행병리취재화전경관찰.결과:①활동성병조내축돌병변십분돌출.기형식포괄유공포양변성、추축혹소실,차외야가견성편적수초송해、단렬혹융합,소돌효질세포변성,이급산재적거서세포.②가의활동성병조내축돌병변정도초경,이공포변성위주,축돌완전소실급추축칙소견,부분수초여축돌적변성급산재적거서세포.결론:만성EAE적병리개변동시존재수초여축돌적변성,다발성경화(multipe sclerosis,MS)후기불가역적공능장애가능여후자유경대적상관.
AIM: To investigate the pathological features of the chronic autoimmune demyelinating disease in central nervous system(CNS) and its clinical significance.METHODS: Experimental allergic encephalomyelitis(EAE) models were established in cynomolgus monkeys. Four year later, the definitely active and indefinitely active EAE tissue blocks were collected and their ultrastructures were studied by electron microscope.loosed, broke up, or were fused with others, while the axonal lesions displayed vacuolar degeneration, crimpled or completely disappeared in those degenerated myelin rings. Some macrophages and degenerated oligodendrocytes changes of axonal lesions were smaller than those of the definitely active lesions. The vacuolar degeneration was the commonest pathological change,but the crimple and disappearance of axons were rarely found. Most inner lamellae of the myelin sheath were loose. Macrophages and degenerated oligodendrocytes were also seen in the tissues.CONCLUSION: Both myelin sheath and axon in the chronic EAE lesions show degenerated changes. Axonal lesion may be related with the irreversible disabilities of the patients with late multiple sclerosis.