CAJ | 학술논문

目的:探讨鼻咽癌(NPC)放射治疗眼部并发症.方法:对213例NPC初程放疗患者进行跟踪观察.放疗前、放疗中及放疗后作视功能(包括远视力、裂隙灯活体显微镜、眼底、自动电脑视野及视诱发电位)检查和角膜荧光素染色.结果:发生角膜损伤19例,占8.9%(19/213).Ⅰ～Ⅱ期6例,Ⅲ期8例,Ⅳ期5例.全部发病患者均无角膜刺激症状,放疗后10mo内,角膜病变消退,但知觉仍较对侧眼明显减退;20mo后尚未恢复正常.未发现晶状体混浊的患者.结论:NPC放疗性角膜损伤与鼻咽癌临床分期及照射剂量无密切关系(P＞0.05),可能主要与角膜感觉神经损伤导致眼表疾病密切相关;不排除患者不同个体对辐射的敏感差异性.
목적:탐토비인암(NPC)방사치료안부병발증.방법:대213례NPC초정방료환자진행근종관찰.방료전、방료중급방료후작시공능(포괄원시력、렬극등활체현미경、안저、자동전뇌시야급시유발전위)검사화각막형광소염색.결과:발생각막손상19례,점8.9%(19/213).Ⅰ～Ⅱ기6례,Ⅲ기8례,Ⅳ기5례.전부발병환자균무각막자격증상,방료후10mo내,각막병변소퇴,단지각잉교대측안명현감퇴;20mo후상미회복정상.미발현정상체혼탁적환자.결론:NPC방료성각막손상여비인암림상분기급조사제량무밀절관계(P＞0.05),가능주요여각막감각신경손상도치안표질병밀절상관;불배제환자불동개체대복사적민감차이성.
AIM: To investigate the ocular complication after radiation therapy for nasopharyngeal carcinoma(NPC).METHODS: The authors performed a previous study on keratopathy in 213 NPC patients who received first stage radiation and had at least 10 months of follow-up. These patients were categorized into three groups depending on NPC clinic stages. Rates and proportions of keratopathy occurring in these groups were compared and analyzed with Chi-square Test and Spearman rank correlation coefficient.RESULTS: Radiation keratopathy developed in 19 patients, about 8.9% (19/213). The latency value was 3 to 30days. The effect of NPC clinic stages and radiation did on the development of keratopathy was not statistically significant (P＞0.05).CONCLUSION: The NPC clinic stages and radiation doses plays few effects on the development of keratopathy. It may play a key role that corneal nerves damage induced ocular surface diseases. It can not be excluded that individuals have different sensitivities to radiation.