CAJ | 학술논문

目的探讨2型糖尿病患者尿nephrin排泄量的变化及其与尿白蛋白排泄量的关系.方法 87例2型糖尿病患者根据尿白蛋白、肌酐比值分为:正常白蛋白尿组,微量白蛋白尿组,临床白蛋白尿组.检测所有入选者尿nephrin(酶联免疫吸附法)及其相关因素.结果健康对照组患者尿中未检测到nephrin排泄,糖尿病组尿液中可检测到nephrin.正常白蛋白尿患者可检测到微量nephrin排泄,大量白蛋白患者尿nephrin/尿肌酐比值显著高于微量白蛋白尿组(P<0.01),尿nephrin/尿肌酐比值与尿白蛋白/尿肌酐呈显著性正相关.结论 2型糖尿病患者尿nephrin排泄增加,并与糖尿病肾病的病情程度有关.
목적 탐토2형당뇨병환자뇨nephrin배설량적변화급기여뇨백단백배설량적관계.방법 87례2형당뇨병환자근거뇨백단백、기항비치분위:정상백단백뇨조,미량백단백뇨조,림상백단백뇨조.검측소유입선자뇨nephrin(매련면역흡부법)급기상관인소.결과 건강대조조환자뇨중미검측도nephrin배설,당뇨병조뇨액중가검측도nephrin.정상백단백뇨환자가검측도미량nephrin배설,대량백단백환자뇨nephrin/뇨기항비치현저고우미량백단백뇨조(P<0.01),뇨nephrin/뇨기항비치여뇨백단백/뇨기항정현저성정상관.결론 2형당뇨병환자뇨nephrin배설증가,병여당뇨병신병적병정정도유관.
Objective To observe the change of the urinary nephrin excretion and its relationship with albuminuria in type 2 diabetics.Methods 87 diabetics were divided into normal albuminuria group,micro-albuminuria group and macro-albuminuria group.Urinary nephrin were measured by enzyme-linked immunosorbent assay.Results Urinary nephrin didn't be detected in normal control group,but its excretion was found increased in the urine of diabetics.The urinary nephrin/ urinary creatinine ratio in macro-albuminuria group was significantly higher than that in micro-albuminuria group,which was positively related with urinary albumin/urinary creatinine ratio.Conclusion Urinary nephrin excretion increases in type 2 diabetics,which is correlated to the degree of diabetic nephropathy.