CAJ | 학술논문

目的探讨BMI与人脑纹状体DAT的相互关系及对99Tcm-TRODAT-1脑SPECT显像的影响.方法 31名健康志愿者(男16名,女15名)分别进行颅脑MRI和99Tcm-TRODAT-1脑SPECT显像.对SPECT图像进行三维重建,参照MRI图像,在SPECT图像横断面纹状体(ST)显示最清楚的连续4层图像上对脑左、右ST(LST、RST)分别进行ROI勾画,取小脑(CB)作为本底参考区,分别计算ST/CB、LST/CB和RST/CB的放射性摄取比值.采用SPSS 15.0软件,分别对ST/CB、LST/CB、RST/CB与BMI、年龄进行Pearson相关性分析;然后以BMI、年龄为自变量,ST/CB为因变量进行多因素回归分析.结果 31名健康志愿者99Tcm-TRODAT-1脑SPECT显像示双侧ST左右对称,放射性前部高于后部.其ST/CB、LST/CB和RST/CB的平均值分别为1.71±0.16,1.70±0.16和1.72±0.17;女性ST/CB、LST/CB和RST/CB的平均值分别为1.74±0.18,1.71±0.19和1.76±0.19;男性ST/CB、LST/CB和RST/CB的平均值分别为1.68±0.14,1.68±0.13和1.69±0.15.ST/CB、LST/CB和RST/CB与BMI均呈负相关(r=-0.53,-0.57,-0.47,P均＜0.05).ST/CB与年龄呈负相关(r=-0.39,P=0.03).多因素回归分析发现仅BMI为显著影响因素(回归系数β=-0.53,t=-3.36,P=0.002).结论健康人脑ST DAT水平随着BMI、年龄的增高而呈降低趋势.女性STDAT水平略高于男性.提示在99Tcm-TRODAT-1脑SPECT显像中,不但要考虑年龄、性别等影响因素,而且要注意BMI也是重要影响因素.
목적 탐토BMI여인뇌문상체DAT적상호관계급대99Tcm-TRODAT-1뇌SPECT현상적영향.방법 31명건강지원자(남16명,녀15명)분별진행로뇌MRI화99Tcm-TRODAT-1뇌SPECT현상.대SPECT도상진행삼유중건,삼조MRI도상,재SPECT도상횡단면문상체(ST)현시최청초적련속4층도상상대뇌좌、우ST(LST、RST)분별진행ROI구화,취소뇌(CB)작위본저삼고구,분별계산ST/CB、LST/CB화RST/CB적방사성섭취비치.채용SPSS 15.0연건,분별대ST/CB、LST/CB、RST/CB여BMI、년령진행Pearson상관성분석;연후이BMI、년령위자변량,ST/CB위인변량진행다인소회귀분석.결과 31명건강지원자99Tcm-TRODAT-1뇌SPECT현상시쌍측ST좌우대칭,방사성전부고우후부.기ST/CB、LST/CB화RST/CB적평균치분별위1.71±0.16,1.70±0.16화1.72±0.17;녀성ST/CB、LST/CB화RST/CB적평균치분별위1.74±0.18,1.71±0.19화1.76±0.19;남성ST/CB、LST/CB화RST/CB적평균치분별위1.68±0.14,1.68±0.13화1.69±0.15.ST/CB、LST/CB화RST/CB여BMI균정부상관(r=-0.53,-0.57,-0.47,P균＜0.05).ST/CB여년령정부상관(r=-0.39,P=0.03).다인소회귀분석발현부BMI위현저영향인소(회귀계수β=-0.53,t=-3.36,P=0.002).결론 건강인뇌ST DAT수평수착BMI、년령적증고이정강저추세.녀성STDAT수평략고우남성.제시재99Tcm-TRODAT-1뇌SPECT현상중,불단요고필년령、성별등영향인소,이차요주의BMI야시중요영향인소.
Objective To assess the relationship between the BMI and the brain DAT, and the influence of BMI on the brain SPECT imaging with 99Tcm-TRODAT-1. Methods MRI and 99Tcm-TRODAT-1SPECT imaging were performed in 31 healthy volunteers(16 males and 15 females), and then the three-dimensional reconstruction of SPECT images were completed. Based on the MRI images, right striatum (RST) and the left striatum (LST) were drawn as ROI on the 4 most clearly consecutive transverse slices.The cerebellum (CB) was taken as the background reference area and the corresponding uptake ratios of ST/CB, LST/CB and RST/CB were calculated. The Pearson correlation tests for radio-uptake ratios (ST/CB, LST/CB, RST/CB), BMI and age were performed, Then multiple linear regression analysis using ST/CB as dependent variable and BMI and age as independent variables was performed. SPSS 15.0 was used in data analysis. Results The ST imaging was symmetrical. The radioactivity was higher in the ST front area than that of the back area. The average uptake ratios of ST/CB, LST/CB, RST/CB were 1.71±0.16,1.70 ± 0. 16 and 1.72±0.17 respectively, in which the three ratios of the female were 1.74 ± 0. 18, 1.71±0. 19 and 1.76 ± 0. 19 respectively and those of the male were 1.68 t 0. 14, 1.68 ± 0. 13 and 1.69± 0.15respectively. ST/CB, LST/CB and RST/CB were negatively correlated with patients'BMI (r = -0. 53,-0.57,-0.47, all P＜0.05). The ST/CB was negatively correlated with patients' age(r=-0.39, P=0. 03). The multiple linear regression analysis showed that the BMI was significant independent variable (β=-0.53, t= -3.36, P=0. 002). Conclusions TheSTDAT,evel may decrease as patients' BMI and age increase. Females' DAT level is slightly higher than males'. For ST DAT imaging, age, gender and BMI should be all taken into consideration.