CAJ | 학술논문

目的:通过检测信号转导与激活因子3(stat-3)与生存素(survivin)在乳腺癌组织中的表达,探讨它们在乳腺癌发生及发展中的意义.方法:应用免疫组织化学法,检测51例乳腺癌和25例癌旁乳腺组织中stat-3和survivin表达.结果:stat-3在乳腺癌中的表达阳性率高于癌旁乳腺组织(P<0.001);stat-3表达在淋巴结转移组中高于无淋巴结转移组(P<0.05).stat-3表达与患者年龄、肿瘤大小、组织学分级、临床分期、雌孕激素受体和c-erbB-2均无明显关系(P>0.05). survivin在乳腺癌中的表达高于癌旁乳腺组织(P<0.001);survivin表达与患者年龄、肿瘤大小、组织学分级、临床分期、淋巴结转移、雌孕激素受体和c-erbB-2均无明显关系(P>0.05).survivin 表达阳性者35例中stat-3表达阳性34例,两者表达呈正相关关系(P<0.05).结论:stat-3、survivin可能相互协同通过抑制细胞凋亡,在乳腺癌发生、发展中起重要作用.
목적:통과검측신호전도여격활인자3(stat-3)여생존소(survivin)재유선암조직중적표체,탐토타문재유선암발생급발전중적의의.방법:응용면역조직화학법,검측51례유선암화25례암방유선조직중stat-3화survivin표체.결과:stat-3재유선암중적표체양성솔고우암방유선조직(P<0.001);stat-3표체재림파결전이조중고우무림파결전이조(P<0.05).stat-3표체여환자년령、종류대소、조직학분급、림상분기、자잉격소수체화c-erbB-2균무명현관계(P>0.05). survivin재유선암중적표체고우암방유선조직(P<0.001);survivin표체여환자년령、종류대소、조직학분급、림상분기、림파결전이、자잉격소수체화c-erbB-2균무명현관계(P>0.05).survivin 표체양성자35례중stat-3표체양성34례,량자표체정정상관관계(P<0.05).결론:stat-3、survivin가능상호협동통과억제세포조망,재유선암발생、발전중기중요작용.
Objective:To investigate the significance of the expression of stat-3 and survivin in the genesis and development of breast carcinoma.Methods:Immunohistochemistry S-P was utilized to measure the expression of stat-3 and survivin protein in 51 breast carcinoma tissues and 25 adjacent noncarcerous tissues.Results:The expression of stat-3 protein was higher in breast carcinoma tissues than that in the adjacent noncarcerous tissues(P<0.001);the expression of stat-3 protein was higher in the positive lymph node group than in the negative lymph node group(P<0.05).It was not related to the patients′ age,size of tumor,pathological grades,clinical stages,ER,PR or cerbB-2(P>0.05).The expression of survivin protein was higer in breast carcinoma tissues than in the adjacent noncarcerous tissues,and the difference was significant(P<0.001).The expression of survivin protein had no significant coorelation with the patients′age,size of tumor,pathological grades,clinical stages,lymph node metastasis,ER,PR or cerbB-2(P>0.05).Of the 35 cases with positive survivin protein expression,positive stat-3 protein was detected in 34 of them.The expression of survivin and stat-3 had positive correlation in breast carcinoma(P<0.05).Conclusions:stat-3 and survivin may play an important role in the carcinogensis and progression of breast carcinoma by inhibiting apoptosis.