CAJ | 학술논문

目的:观察新辅助化疗对乳腺癌外周血微转移因子的影响.方法:以48例具备新辅助化疗条件的乳腺癌患者为研究对象,采用RT-PCR技术,联合检测外周血中CK-19mRNA、VEGFmRNA和hMAMmRNA的表达,观察新辅助化疗前后血微转移因子变化.结果:本组乳腺癌微转移因子阳性率在病理分级中差异无显著性意义(P>0.05);在分期中,分期越高阳性率越高(P<0.05);化疗方案可影响微转移因子阳性率的变化(P<0.01).结论:通过检测乳腺癌患者外周血中微转移因子,有可能成为判断乳腺癌预后和指导治疗的指标.
목적:관찰신보조화료대유선암외주혈미전이인자적영향.방법:이48례구비신보조화료조건적유선암환자위연구대상,채용RT-PCR기술,연합검측외주혈중CK-19mRNA、VEGFmRNA화hMAMmRNA적표체,관찰신보조화료전후혈미전이인자변화.결과:본조유선암미전이인자양성솔재병리분급중차이무현저성의의(P>0.05);재분기중,분기월고양성솔월고(P<0.05);화료방안가영향미전이인자양성솔적변화(P<0.01).결론:통과검측유선암환자외주혈중미전이인자,유가능성위판단유선암예후화지도치료적지표.
Objective:To explore the influence of neoadjuvant chemotherapy on peripheral micrometastasis factors in breast cancer.Methods:CK-19mRNA,VEGFmRNA and hMAMmRNA in peripheral blood of 48 breast cancer patients were detected using RT-PCR before and after neoadjuvant chemotherapy.Results:No significant difference in the breast micrometastasis factors was noted in different pathological stages (P>0.05); the positive rate of micrometastasis factors was higher in upper clinical stages(P<0.05).Chemotherapy had positive effect on micrometastasis factors (P<0.01).Conclusion:The factors of peripheral micrometastasis could be tested for breast cancer patients,guiding prognosis and treatment.