中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2011年
32期
9-11
,共3页
异甘草酸镁(天晴甘美)%多烯磷脂酰胆碱%谷胱甘肽%肝硬化%黄疸%梗阻性
異甘草痠鎂(天晴甘美)%多烯燐脂酰膽堿%穀胱甘肽%肝硬化%黃疸%梗阻性
이감초산미(천청감미)%다희린지선담감%곡광감태%간경화%황달%경조성
Magnesium isoglycyrrhizinate injection%Polyene phosphatidylcholine%Glutathione%Liver cirrhosis%Jaundice,obstructive
目的 探讨异甘草酸镁(天晴甘美)、多烯磷脂酰胆碱(PPC)和还原型谷胱甘肽(GSH)对肝硬化合并良性梗阻性黄疸患者术后的应用效果.方法 选取肝硬化合并胆管结石导致的良性梗阻性黄疸患者59例,所有患者术前均采用天晴甘美和GSH护肝治疗,按手术实施日期的奇偶数分为两组,31例奇数患者加用PPC治疗(A组),28例偶数患者继续术前护肝治疗方案(B组),比较两组患者术后1、3、7d的丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总胆红素(TBIL)、胆碱酯酶(ChE)、前白蛋白(PA)水平变化.结果 A组和B组中分别有3例、4例被剔除该研究.A组术后3、7d的ALT[(193±48)、(63±17)U/L]、AST[(194±57)、(54±19)U/L]、TBIL[(99±20)、(28±9)μmol/L]水平明显低于B组[分别为(235±50)、(103±33)U/L,(235±64)、(82±22)U/L,(127±45)、(43±18)μmol/L](P＜0.05),ChE[(3781±294)、(4405±469)U/L]、PA[(0.22±0.07)、(0.30±0.04)g/L]水平明显高于B组[分别为(3449±431)、(4105±546)U/L,(0.18±0.07)、(0.25±0.05)g/L](P＜ 0.05);A组术后ChE和PA水平均较前次测得的ChE、PA水平明显上升(P＜0.05),B组术后7d较术后3d恢复明显(P＜0.05).结论 肝硬化合并良性梗阻性黄疸术后患者,联合应用天晴甘美、PPC和GSH肝细胞保护剂可有效抑制肝细胞损伤,促进术后肝功能的恢复.
目的 探討異甘草痠鎂(天晴甘美)、多烯燐脂酰膽堿(PPC)和還原型穀胱甘肽(GSH)對肝硬化閤併良性梗阻性黃疸患者術後的應用效果.方法 選取肝硬化閤併膽管結石導緻的良性梗阻性黃疸患者59例,所有患者術前均採用天晴甘美和GSH護肝治療,按手術實施日期的奇偶數分為兩組,31例奇數患者加用PPC治療(A組),28例偶數患者繼續術前護肝治療方案(B組),比較兩組患者術後1、3、7d的丙氨痠氨基轉移酶(ALT)、天鼕氨痠氨基轉移酶(AST)、總膽紅素(TBIL)、膽堿酯酶(ChE)、前白蛋白(PA)水平變化.結果 A組和B組中分彆有3例、4例被剔除該研究.A組術後3、7d的ALT[(193±48)、(63±17)U/L]、AST[(194±57)、(54±19)U/L]、TBIL[(99±20)、(28±9)μmol/L]水平明顯低于B組[分彆為(235±50)、(103±33)U/L,(235±64)、(82±22)U/L,(127±45)、(43±18)μmol/L](P＜0.05),ChE[(3781±294)、(4405±469)U/L]、PA[(0.22±0.07)、(0.30±0.04)g/L]水平明顯高于B組[分彆為(3449±431)、(4105±546)U/L,(0.18±0.07)、(0.25±0.05)g/L](P＜ 0.05);A組術後ChE和PA水平均較前次測得的ChE、PA水平明顯上升(P＜0.05),B組術後7d較術後3d恢複明顯(P＜0.05).結論 肝硬化閤併良性梗阻性黃疸術後患者,聯閤應用天晴甘美、PPC和GSH肝細胞保護劑可有效抑製肝細胞損傷,促進術後肝功能的恢複.
목적 탐토이감초산미(천청감미)、다희린지선담감(PPC)화환원형곡광감태(GSH)대간경화합병량성경조성황달환자술후적응용효과.방법 선취간경화합병담관결석도치적량성경조성황달환자59례,소유환자술전균채용천청감미화GSH호간치료,안수술실시일기적기우수분위량조,31례기수환자가용PPC치료(A조),28례우수환자계속술전호간치료방안(B조),비교량조환자술후1、3、7d적병안산안기전이매(ALT)、천동안산안기전이매(AST)、총담홍소(TBIL)、담감지매(ChE)、전백단백(PA)수평변화.결과 A조화B조중분별유3례、4례피척제해연구.A조술후3、7d적ALT[(193±48)、(63±17)U/L]、AST[(194±57)、(54±19)U/L]、TBIL[(99±20)、(28±9)μmol/L]수평명현저우B조[분별위(235±50)、(103±33)U/L,(235±64)、(82±22)U/L,(127±45)、(43±18)μmol/L](P＜0.05),ChE[(3781±294)、(4405±469)U/L]、PA[(0.22±0.07)、(0.30±0.04)g/L]수평명현고우B조[분별위(3449±431)、(4105±546)U/L,(0.18±0.07)、(0.25±0.05)g/L](P＜ 0.05);A조술후ChE화PA수평균교전차측득적ChE、PA수평명현상승(P＜0.05),B조술후7d교술후3d회복명현(P＜0.05).결론 간경화합병량성경조성황달술후환자,연합응용천청감미、PPC화GSH간세포보호제가유효억제간세포손상,촉진술후간공능적회복.
Objective To explore ffie effects of magnesium isoglycyrrhizinate injection,polyene phosphatidylcholine(PPC)and reduced glutathione(GSH)in patients with liver cirrhosis accompanied by benign obstructive jaundice after surSery.Methods Fifty-nine patients with liver cirrhosis and benign obstructive jaundice caused by gallstones were selected,and all of them were treated with magnesium isoglycyrrhizinate injection and GSH preoperatively.Thirty-one odd number patients received magnesium isoglycyrrhizinate injection,PPC and GSH treatment(group A)after surgery immediately,28 even number patients still continued to be treated with magnesium isoglycyrrhizinate injection and GSH(group B).The plasma alanine aminotransferase(ALT),aspartate aminotramsferase(AST),total cholesterol(TBIL)and cholinesterase(ChE),and prealbumin at the time of 1,3 and 7 day after surgery were compared between the two groups.Results Seven patients were excluded from this research including 3 cases in group A,4 cases in group B.The plasma ALT,AST,TBIL of the group A at postoperative 3,7 day[(193 ± 48)and(63 ± 17)U/L,(194 ± 57)and(54 ± 19)U/L,(99 ± 20)and(28 ± 9)μmol/L]were significantly lower than those of the group B[(235 ± 50)and(103 ± 33)U/L,(235 ± 64)and(82 ± 22)U/L,(127 ± 45)and(43 ± 18)μ mol/L,respectively](P＜ 0.05),whereas the plasma ChE and prealbumin of the group A[(3781 ± 294)and(4405 ± 469)U/L,(0.22 ± 0.07)and(0.30 ± 0.04)g/L]were significantly higher than those of the there were obvious differences of the plasma ChE and prealbumin at postoperative 3 or 7 day compared with those at postoperative 1 or 3 day in the group A(P ＜ 0.05).But this were improved at postoperative 7 day compared with those at postoperative 3 day in the group B(P＜ 0.05).Conclusion Combined treatment of magnesium isoglycyrrhizinate injection,PPC and GSH can be more effective to reduce the injury of the liver cells and promote the recovery of liver function for patients with liver cirrhosis and obstructive jaundice.
