CAJ | 학술논문

目的评价血液中基质金属蛋白酶组织抑制因子(TIMP)-1与儿童心肌炎的关系,验证临床检测TIMP-1的意义.方法将年龄为1～14岁临床诊断为心肌炎患者9例与相匹配的对照组9例取血标本,测定门冬氨酸氨基转移酶(AST)、乳酸脱氢酶(LDH)、肌酸激酶(CK)、α-羟丁酸脱氢酶(HBDH)、肌酸激酶同工酶(CKMB),心肌肌钙蛋白Ⅰ(cTnI)、C反应蛋白及TIMP-1,并行超声心动图等检查.结果超声心动图示心肌炎患儿射血分数显著降低、左心室扩大.儿童心肌炎患者TIMP-1水平较对照组显著降低.心肌炎患儿与对照组心肌酶、心肌肌钙蛋白Ⅰ、C反应蛋白及检测差异均无统计学意义.结论对儿童心肌炎患者来说,血液中的TIMP-1水平可能能够显示其疾病的严重程度,且TIMP-1降低可能是心肌炎进展为扩张性心肌病的机制之一.
목적 평개혈액중기질금속단백매조직억제인자(TIMP)-1여인동심기염적관계,험증림상검측TIMP-1적의의.방법 장년령위1～14세림상진단위심기염환자9례여상필배적대조조9례취혈표본,측정문동안산안기전이매(AST)、유산탈경매(LDH)、기산격매(CK)、α-간정산탈경매(HBDH)、기산격매동공매(CKMB),심기기개단백Ⅰ(cTnI)、C반응단백급TIMP-1,병행초성심동도등검사.결과 초성심동도시심기염환인사혈분수현저강저、좌심실확대.인동심기염환자TIMP-1수평교대조조현저강저.심기염환인여대조조심기매、심기기개단백Ⅰ、C반응단백급검측차이균무통계학의의.결론 대인동심기염환자래설,혈액중적TIMP-1수평가능능구현시기질병적엄중정도,차TIMP-1강저가능시심기염진전위확장성심기병적궤제지일.
Objective To evaluate the relationship between serum tissue inhibitors of metaUoproteinase-1 and children with myocarditis,and provide evidences to support the measurement of serum tissue inhibitors of metallopro- teinase-1. Methods Tissue inhibitors of metalloproteinaee-1 and bioehem indexes of the harvested specimens and e -chocardiogram were measured from children with myocarditis(age: 1～14 years old, n = 9) and healthy young chil- dren(age: 1～14 years old, n = 9). Results Children with myocarditis showed reduced ejection fraction and dilated left ventricular compared with healthy children. Tissue inhibitors of metalloproteinaee-1 in children with myocarditis was significantly reduced compared with healthy children. Aspartie acid transanainase, lactate dehydrogenase,creatine kinase, hydroxybutyrie acid dehydrogenase, MB isoenzyrne of creatine kinase, cardiac troponin Ⅰ , C reactive protein showed no difference between two groups. Conclusion The reduced serum level of tissue inhibitors of metallopro- teinase-1 may show the severity of children with myocarditis and maybe one of the mechanisms of children with di- lated cardiomyopathy following myocarditis.