中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2012年
8期
867-869
,共3页
刘宁%刘春林%冯超%张进生%渠渊
劉寧%劉春林%馮超%張進生%渠淵
류저%류춘림%풍초%장진생%거연
托特罗定%盆底电刺激%女性膀胱过度活动症
託特囉定%盆底電刺激%女性膀胱過度活動癥
탁특라정%분저전자격%녀성방광과도활동증
Tolterodine%Pelvic floor electrical stimulation%Female overactive bladder
目的 观察托特罗定联合盆底神经电刺激治疗女性膀胱过度活动症的效果并探讨其作用机制.方法 将2009年10月至2010年12月就诊的73例女性膀胱过度活动症患者随机分为两组:托特罗定组口服托特罗定2 mg/次,2次/d,疗程4周；联合治疗组口服托特罗定2 m/次,2次/d,加用盆底神经电刺激治疗,隔日1次,疗程4周.结果 与治疗前比较,两组患者的膀胱过度活动症状(尿急、急迫性尿失禁、排尿次数、每次排尿量)减轻(P均＜0.05).两组之间比较,在减轻尿急次数、尿失禁次数及夜尿次数指标上,两组差异无统计学意义(P均＞0.05),但联合治疗组在减少每日排尿次数[(5.6±0.1)次]及每次排尿量[(248±14.6)ml]的增加方面优于托特罗定组[(7.6±0.3)次、(207±11.3)ml],差异有统计学意义(P均＜0.05).结论 托特罗定联合盆底神经电刺激能明显改善女性OAB症状,提高患者生活质量,疗效优于单用托特罗定,有一定临床意义.
目的 觀察託特囉定聯閤盆底神經電刺激治療女性膀胱過度活動癥的效果併探討其作用機製.方法 將2009年10月至2010年12月就診的73例女性膀胱過度活動癥患者隨機分為兩組:託特囉定組口服託特囉定2 mg/次,2次/d,療程4週；聯閤治療組口服託特囉定2 m/次,2次/d,加用盆底神經電刺激治療,隔日1次,療程4週.結果 與治療前比較,兩組患者的膀胱過度活動癥狀(尿急、急迫性尿失禁、排尿次數、每次排尿量)減輕(P均＜0.05).兩組之間比較,在減輕尿急次數、尿失禁次數及夜尿次數指標上,兩組差異無統計學意義(P均＞0.05),但聯閤治療組在減少每日排尿次數[(5.6±0.1)次]及每次排尿量[(248±14.6)ml]的增加方麵優于託特囉定組[(7.6±0.3)次、(207±11.3)ml],差異有統計學意義(P均＜0.05).結論 託特囉定聯閤盆底神經電刺激能明顯改善女性OAB癥狀,提高患者生活質量,療效優于單用託特囉定,有一定臨床意義.
목적 관찰탁특라정연합분저신경전자격치료녀성방광과도활동증적효과병탐토기작용궤제.방법 장2009년10월지2010년12월취진적73례녀성방광과도활동증환자수궤분위량조:탁특라정조구복탁특라정2 mg/차,2차/d,료정4주；연합치료조구복탁특라정2 m/차,2차/d,가용분저신경전자격치료,격일1차,료정4주.결과 여치료전비교,량조환자적방광과도활동증상(뇨급、급박성뇨실금、배뇨차수、매차배뇨량)감경(P균＜0.05).량조지간비교,재감경뇨급차수、뇨실금차수급야뇨차수지표상,량조차이무통계학의의(P균＞0.05),단연합치료조재감소매일배뇨차수[(5.6±0.1)차]급매차배뇨량[(248±14.6)ml]적증가방면우우탁특라정조[(7.6±0.3)차、(207±11.3)ml],차이유통계학의의(P균＜0.05).결론 탁특라정연합분저신경전자격능명현개선녀성OAB증상,제고환자생활질량,료효우우단용탁특라정,유일정림상의의.
Objective To investigate whether tolterodine combined with pelvic floor electrical stimulation is more effective than tolterodine alone in the treatment of wonen with overactive bladder(OAB) and the underlying mechanism.Methods Seventy-three female patients with OAB were recruited from our hospital during Oct.2009 to Dec.2010 and prospectively studied,of whom 39 cases were given tolterodine(2 mg each time,twice daily for4 weeks)alone while the other 34 cases were given tolterodine combined with pelvic floor electrical stimulation for the treatment of OAB.Data on urgency,incontinence,micturition frequency,nocturia episodes and voided volume were collected before and after 4 weeks' treatment using a week micturition diary.Results The differences of changes of OAB symptoms between the 2 groups had statistical significance (P ＜ 0.05).Patients in the tolterodine combined with pelvic floor electrical stimulation group reported treatment benefit than the tolterodine group in the micturitions and the volume voided per micturition(P ＜ 0.05).There were no difference in the number of urgency episodes per 24 hours,incontinence episodes and nocturnal episodes (P ＞ 0.05).Conclusion A combination of toterodine with pelvic floor electrical stimulation could significantly improve the OAB symptoms,and is a potential therapy for female patients with OAB.
