国际脑血管病杂志
國際腦血管病雜誌
국제뇌혈관병잡지
INTERNATIONAL JOURNAL OF CEREBROVASCULAR DISEASES
2011年
6期
457-460
,共4页
脑淀粉样血管病%淀粉样β蛋白肽%载脂蛋白E
腦澱粉樣血管病%澱粉樣β蛋白肽%載脂蛋白E
뇌정분양혈관병%정분양β단백태%재지단백E
Cerebral amyloid angiopathy%Amyloid β-peptides%Apolipoproteins E
脑淀粉样血管病(cerebral amyloid angiopathy,CAA)以软脑膜和皮质中小动脉壁内的β-淀粉样蛋白沉积为特征,是老年人的常见脑血管病变之一,与阿尔茨海默病、脑出血、脑梗死和白质脑病相关.CAA分为遗传性和散发性2种形式,以后者居多.文章就散发性CAA的病理生理学机制研究进展,特别是脑组织β-淀粉样蛋白的产生和清除机制进行了综述.
腦澱粉樣血管病(cerebral amyloid angiopathy,CAA)以軟腦膜和皮質中小動脈壁內的β-澱粉樣蛋白沉積為特徵,是老年人的常見腦血管病變之一,與阿爾茨海默病、腦齣血、腦梗死和白質腦病相關.CAA分為遺傳性和散髮性2種形式,以後者居多.文章就散髮性CAA的病理生理學機製研究進展,特彆是腦組織β-澱粉樣蛋白的產生和清除機製進行瞭綜述.
뇌정분양혈관병(cerebral amyloid angiopathy,CAA)이연뇌막화피질중소동맥벽내적β-정분양단백침적위특정,시노년인적상견뇌혈관병변지일,여아이자해묵병、뇌출혈、뇌경사화백질뇌병상관.CAA분위유전성화산발성2충형식,이후자거다.문장취산발성CAA적병리생이학궤제연구진전,특별시뇌조직β-정분양단백적산생화청제궤제진행료종술.
Cerebral amyloid angiopathy (CAA) is characterized by leptomeningeal and β-amyloid deposition in arteriole wall in cortex, and it is one of the common cerebral vascular diseases in the elderly. It is correlated with Alzheimer's disease, intracerebral hemorrhage, cerebral infarction and leukoencephalopathy. CAA is divided into hereditary and sporadic types, and the latter is most common. This article reviews the advances in research on the pathophysiological mechanisms of sporadic CAA, particularly the production of β-amyloid protein and clearance mechanism in brain tissue.
