CAJ | 학술논문

氯吡格雷是缺血性卒中治疗的基本药物,被多国卒中治疗指南所推荐,广泛应用于临床.有不少缺血性卒中患者在经过规范氯吡格雷治疗后仍然复发卒中,因此必须重视氯吡格雷抵抗现象.文章对氯吡格雷抵抗的生化机制、基因多态性、实验室检测及其应对措施进行了综述.
록필격뢰시결혈성졸중치료적기본약물,피다국졸중치료지남소추천,엄범응용우림상.유불소결혈성졸중환자재경과규범록필격뢰치료후잉연복발졸중,인차필수중시록필격뢰저항현상.문장대록필격뢰저항적생화궤제、기인다태성、실험실검측급기응대조시진행료종술.
Clopidogrel is an essential drug for the treatment of ischemic stroke.It has been recommended by the multinational stroke treatment guidelines and has been widely used in clinical practice.Many patients with ischemic stroke may still have stroke recurrence after the standard treatment of clopidogrel; therefore,we must pay attention to the phenomenon of clopidogrel resistance.This article reviews the biochemical mechanisms,gene polymorphism,laboratory testing,and response measures of clopidogrel resistance.